Recombinant Human CSF1 (33-190aa), Met tagged


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Recombinant Human CSF1 (33-190aa), Met tagged

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Cat. No. : CSF1-033E
Product Overview : Recombinant Human CSF1 (Glu33-Ser190, with an N­terminal Met) was expressed in E. coli and produced using non­animal reagent in an animal­free laboratory.
Description : M­CSF, also known as CSF­1, is a four-­α­-helical bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M­CSF is also essential for the survival and proliferation of osteoclast progenitors. M­CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis . M­CSF increases during pregnancy to support implantation and growth of the decidua and placenta. Sources of M­CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells.
Source : E. coli
N­terminal Sequence Analysi : Met
Molecular Mass : 18.5 kDa
SDS­PAGE : 37 kDa, non­reducing conditions
Activity : Measured in a cell proliferation assay using M­NFS­60 mouse myeloid cells. The ED50 for this effect is typically 0.5 ­ 1.5 ng/mL.
Endotoxin Leve : <1.0 EU per 1μg of the protein by the LAL method.
Purity : >97%, by SDS­PAGE under reducing conditions and visualized by silver stain.
Formulation : Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details.
Reconstitution : Reconstitute at 200 μg/mL in sterile PBS.
Shipping : The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage : Use a manual defrost freezer and avoid repeated freeze­thaw cycles. 1. 12 months from date of receipt, ­20 to ­70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, ­20 to ­70 °C under sterile conditions after reconstitution.
Unitprot ID : P09603
PDB rendering basedon 1hmc. :

Gene Name : CSF1 colony stimulating factor 1 (macrophage) [ Homo sapiens ]
Official Symbol : CSF1
Synonyms : CSF1; colony stimulating factor 1; MCSF; MGC31930; macrophage colony-stimulating factor 1; CSF-1; lanimostim; macrophage colony stimulating factor
Gene ID : 1435
mRNA Refseq : NM_000757
Protein Refseq : NP_000748
MIM : 120420
Chromosome Location : 1p21-p13
Pathway : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Osteoclast differentiation; Rheumatoid arthritis; Signaling events mediated by PTP1B; Signaling events mediated by TCPTP
Function : cytokine activity; growth factor activity; macrophage colony-stimulating factor receptor binding; protein homodimerization activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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