"CXCL9" Related Products


Recombinant Human Chemokine (C-X-C Motif) Ligand 9

Cat. No.: CXCL9-17H
Product Overview: Recombinant Human MIG/CXCL9 produced in E. coli is a single, non-glycosylated polypeptide chain containing 103 amino acids and having a molecular mass of 11.7 kDa.
Description: CXCL9, a member of the α subfamily of chemokines that lack the ELR domain, was initially identified as a lymphokine-activated gene in mouse macrophages. The CXCL9 gene is induced in macrophages and in primary glial cells of the central nervous system specifically in response to IFN-γ. CXCL9 has been shown to be a chemoattractant for activated T-lymphocytes and TIL but not for neutrophils or monocytes. The human CXCL9 cDNA encodes a 125 amino acid residue precursor protein with a 22 amino acid residue signal peptide that is cleaved to yield a 103 amino acid residue mature protein. CXCL9 has an extended carboxy-terminus containing greater than 50% basic amino acid residues and is larger than most other chemokines. A chemokine receptor (CXCR3) specific for CXCL9 and IP-10 has recently been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.
Purity: >97% by SDS-PAGE and HPLC analyses.
Formulation: Lyophilized from a 0.2mm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 50mM NaCl.
Specific Activity: Fully biologically active when compared to standard. Determined by its ability to chemoattract human peripheral blood T-Lymphocytes using a concentration range of 10.0-100.0 ng/ml.
Endotoxin: Less than 1EU/mg of rHuMIG/CXCL9 as determined by LAL method.
Reconstitutionon: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at<-20°C. Further dilutions should be made in appropriate buffered solutions.
Storagee: This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name: CXCL9 chemokine (C-X-C motif) ligand 9
Synonyms: CMK; MIG; Humig; SCYB9; crg-10; Gamma-interferon-induced monokine; Small-inducible cytokine B9; chemokine (C-X-C motif) ligand 9; monokine induced by gamma interferon; small inducible cytokine B9; CXCL9_HUMAN; C-X-C motif chemokine 9 [Precursor]; Gamma-interferon-induced monokine; CXCL9
Gene ID: 4283
mRNA Refseq: NM_002416
Protein Refseq: NP_002407
MIM: 601704
UniProt ID: Q07325
Chromosome Location: 4q21
Pathway: Cytokine-cytokine receptor interaction;Toll-like receptor signaling pathway
Function: chemokine activity

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