Recombinant Human SMAD Family Member 1, GST-tagged SMAD1-1092H

Cat. No.:	SMAD1-1092H
Product Overview:	Recombinant full-length human SMAD1 was expressed in E. coli cells using an N-terminal GST tag.
Description:	SMAD1 is a member of the SMAD family which are signal transducers and transcriptional modulators that mediate multiple signaling pathways. The actions of bone morphogenetic proteins (BMPs) are mediated by SMAD1 and SMAD1 can be phosphorylated and activated by the BMP receptor kinase. Phosphorylated SMAD1 forms a complex with SMAD4 that is important for its function in the transcription regulation.
Applications:	Kinase Assay; Western Blot
Molecular Weight:	83 kDa
Expression System:	E. coli
Species:	Human
Form:	Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol.
Purity:	> 90 %
Concentration:	0.2 ug/ul
Sequences:	Full-length
Storage:	Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways:	ALK1 signaling events; ALK2 signaling events; BMP receptor signaling; Delta-Notch Signaling Pathway; ErbB1 downstream signaling; Heart Development; Id Signaling Pathway; Signaling by BMP; TGF Beta Signaling Pathway

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Gene Name:	SMAD1 SMAD family member 1 [ Homo sapiens ]
Official Symbol:	SMAD1
Synonyms:	SMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; OTTHUMP00000220455; OTTHUMP00000220456; OTTHUMP00000221520; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1; MAD, mothers against decapentaplegic homolog 1 (Drosophila); Mothers against decapentaplegic homolog 1; Mad-related protein 1; Transforming growth factor-beta-signaling protein 1
Gene ID:	4086
mRNA Refseq:	NM_001003688
Protein Refseq:	NP_001003688
MIM:	601595
UniProt ID:	Q15797
Chromosome Location:	4q31.21
Function:	RNA polymerase II transcription factor activity; co-SMAD binding; identical protein binding; protein kinase binding; receptor signaling protein activity; transcription activator activity; transcription factor activity; transforming growth factor beta receptor