| Cat. No. : |
SMAD1-1092H |
| Product Overview : |
Recombinant full-length human SMAD1 was expressed in E. coli cells using an N-terminal GST tag. |
| Description : |
SMAD1 is a member of the SMAD family which are signal transducers and transcriptional modulators that mediate multiple signaling pathways. The actions of bone morphogenetic proteins (BMPs) are mediated by SMAD1 and SMAD1 can be phosphorylated and activated by the BMP receptor kinase. Phosphorylated SMAD1 forms a complex with SMAD4 that is important for its function in the transcription regulation. |
| Applications : |
Kinase Assay; Western Blot |
| Molecular Weight : |
83 kDa |
| Expression System : |
E. coli |
| Species : |
Human |
| Form : |
Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
| Purity : |
> 90 % |
| Concentration : |
0.2 ug/ul |
| Sequences : |
Full-lengt h |
| Storage : |
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways : |
ALK1 signaling events; ALK2 signaling events; BMP receptor signaling; Delta-Notch Signaling Pathway; ErbB1 downstream signaling; Heart Development; Id Signaling Pathway; Signaling by BMP; TGF Beta Signaling Pathway |
| PDBrendering based on 1khu. : |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.