Recombinant Human Tumor Protein P73, GST-tagged


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Recombinant Human Tumor Protein P73, GST-tagged

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Cat. No. : TP73-329H
Product Overview : Full-length recombinant human TP73 beta was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : TP73β is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The TP73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. P73β is strongly involved in malignancy acquisition and maintenance. TP73 is a stress-response gene that activates transcription of p53-responsive genes and inhibits cell growth in a p53-like manner by inducing apoptosis. TP73 is a component of a mismatch repair-dependent apoptosis pathway, which contributes to cisplatin-induced cytotoxicity. The regulation of TP73 by c-Abl in response to DNA damage was also demonstrated by a failure of ionizing radiation-induced apoptosis after disruption of c-Abl-p73 interaction.
Applications : Western Blot
Molecular Weight : 88kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50mM Tris-HCI, pH 7.5, 150mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25% glycerol.
Purity : >95%
Concentration : 0.2ug/ul
Sequences : Full-lengt h
Storage : Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on dry ice.
Pathways : Alpha6-Beta4 Integrin Signaling Pathway; Alpha6-Beta4 Integrin Signaling Pathway; Direct p53 effectors; E2F transcription factor network; Measles; Neurotrophin signaling pathway; TGF-beta Receptor Signaling Pathway; TP53 network; p53 signaling pathway
PDBrendering based on 1cok. :

Gene Name : TP73 tumor protein p73 [ Homo sapiens ]
Official Symbol : TP73
Synonyms : TP73;tumor protein p73; P73, OTTHUMP00000000662; OTTHUMP00000003477; OTTHUMP00000003478; OTTHUMP00000003479; OTTHUMP00000003480; p53-related protein; p53-like transcription factor
Gene ID : 7161
mRNA Refseq : NM_005427
Protein Refseq : NP_005418
MIM : 601990
UniProt ID : O15350
Chromosome Location : 1p36.3
Function : Transcription repressor activity; Transcription factor binding; Transcription activator activity; Sequence-specific DNA binding transcription factor activity; Protein binding; promoter binding; p53 binding; Metal ion binding; Double-stranded DNA binding; Damaged DNA binding; Chromatin binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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