Recombinant Human Hypoxanthine Phosphoribosyltransferase 1, His-tagged

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Recombinant Human Hypoxanthine Phosphoribosyltransferase 1, His-tagged

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Cat. No. : HPRT1-1796H
Product Overview : Recombinant human HPRT1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Description : Hypoxanthine-guanine phosphoribosyltransferase, also known as HPRT1 has a central role in the generation of purine nucleotides through the purine salvage pathway. The enzyme primarily functions to salvage purines from degraded DNA to renewed purine synthesis. In this role, it acts as a catalyst in the reaction between guanine and phosphoribosyl pyrophosphate to form GMP.
Concentration : 0.5 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol.
Purity : > 95% by SDS - PAGE
Sequence : 1-218 amino acids: MGSSHHHHHH SSGLVPRGSH MATRSPGVVI SDDEPGYDLD LFCIPNHYAE DLERVFIPHG LIMDRTERLA RDVMKEMGGH HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI RLKSYCNDQS TGDIKVIGGD DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV RQYNPKMVKV ASLLVKRTPR SVGYKPDFVG FEIPDKFVVG YALD
Molecular Mass : 26.7 kDa (238aa), confirmed by MALDI-TOF
Applications : SDS-PAGE
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Ribbon diagram of ahuman HPRT tetramer. Magnesium ions visible in green. From PDB 1BZY. :

Gene Name : HPRT1 hypoxanthine phosphoribosyltransferase 1 [ Homo sapiens ]
Official Symbol : HPRT1
Synonyms : HPRT1; hypoxanthine phosphoribosyltransferase 1; HPRT; HGPRT; hypoxanthine-guanine phosphoribosyltransferase; HGPRTase; EC 2.4.2.8; Lesch-Nyhan syndrome
Gene ID : 3251
mRNA Refseq : NM_000194
Protein Refseq : NP_000185
MIM : 308000
UniProt ID : P00492
Chromosome Location : Xq26.1
Pathway : Drug metabolism - other enzymes; Metabolic pathways; Purine metabolism
Function : hypoxanthine phosphoribosyltransferase activity; magnesium ion binding; protein binding; protein homodimerization activity; transferase activity, transferring glycosyl groups
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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