Recombinant Human Heat Shock Protein 90kDa Beta (Grp94), Member 1 HSP90B1-07H

Recombinant Human Heat Shock Protein 90kDa Beta (Grp94), Member 1


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Recombinant Human Heat Shock Protein 90kDa Beta (Grp94), Member 1

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Cat. No. : HSP90B1-07H
Product overview : Recombinant Human heat shock protein 90β produced in E. coli has a molecular mass of approximately 85 KDa.
Description : An approximately 90 kDa heat shock protein constitutively expressed in the cytoplasm. It exists as a dimer and has been observed to bind other cellular proteins such as p60v-src, steroid receptors, heme-regulated protein kinase, actin, and tubulin. Bind to histones with high affinity and induces chromatin condensation.
Source : E. coli.
Purity : >95% as determined by SDS-PAGE.
Specific Activity : The biological activity ofHSP90B1 is measured by its ability to support survival and stimulate neurite outgrowth of cultured embryonic chick dorsal root ganglia. Activity can also be measured by its ability to bind recombinant human GFRα1/Fc.
Storage Buffer : Liquid. In PBS Buffer. Avoid freeze/thaw cycles.
Solid ribbon model of the yeast Hsp90-dimer (α-helices= red,β-sheets= cyan, loops = grey) in complex with ATP (red stick diagram) based onPDB2CG9. :

Gene Name : HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 [ Homo sapiens ]
Synonyms : ECGP; GP96; GRP94; TRA1;94 kDa glucose-regulated protein; Endoplasmin precursor; Heat shock protein 90 kDa beta member 1; Tumor rejection antigen 1; Tumor rejection antigen-1 (gp96); endothelial cell (HBMEC) glycoprotein; glucose regulated protein; 94 kDa; gp96 homolog; heat shock protein 90kDa beta (Grp94), member 1; tumor rejection antigen (gp96) 1
Gene ID : 7184
mRNA Refseq : NM_003299
Protein Refseq : NP_003290
MIM : 191175
Uniprot ID : O95433
Chromosome Location : 12q24.2-q24.3
Pathway : Pathways in cancer; Prostate cancer
Function : ATP binding, RNA binding, calcium ion binding, low-density lipoprotein receptor binding, nucleotide binding, unfold protein binding, virion binding

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