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Recombinant Human Interleukin-1 Receptor Antagonist

Cat. No.: IL1RN-05H
Product Overview: Recombinant Human IL-1RN produced inE. coliis a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17258 Dalton.
Description: Interleukin-1 receptor antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups.
Purity: >95% as determined by RP-HPLC, FPLC and SDS-PAGE.
Formulation: IL-1RN was lyophilized after extensive dialysis against PBS.
Specific Activity: The ED50 as determined by the dose-dependant inhibition of IL-1 stimulation of D10S cells was found to be 0.5 ng/ml, corresponding to a Specific Activity of 2.0 x 106IU/mg.
Endotoxin: Less than 0.1ng/µg (1IEU/µg) of IL-1RN.
Reconstitution: It is recommended to reconstitute the lyophilized rHuIL-1RN in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage: Lyophilized rHuIL-1RN although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuIL-1RN should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HAS or BSA). Aliquot to avoid repeated freeze-thaw cycles.
Gene Name: IL1RN
Synonyms: ICIL-1RA, IL-1ra3, IL1F3, IL1RA, IRAP, RAP, IL1 inhibitor, MGC10430;IL-1ra,IL-1RN, Anakinra, Interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); Interleukin-1 receptor antagonist protein precursor; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); type II interleukin-1 receptor antagonist
Gene ID: 3557
mRNA Refseq: NM_000577
Protein Refseq: NP_000568
MIM: 147679
UniProt ID: P18510
Chromosome Location: 2q14.2
Function: interleukin-1 receptor antagonist activity; protein binding activity

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