"IL13" Related Products


Recombinant Human Interleukin-13

Cat. No.: IL13-22H
Product Overview: Recombinant Human Interleukin-13 produced inE.coliis a single non-glycosylated polypeptide chain containing 112 amino acids and having a molecular mass of approximately 12 kDa.
Description: The human IL-13 cDNA encodes a 132 amino acid protein containing a proposed 20 amino acid signal peptide. Human IL-13 shares approximately 30% amino acid sequence homology to human IL-4 and the two cytokines exhibit overlapping biological activities. Human IL-13 is produced by activated Th0, Th1-like Th2-like and CD8 T cells. Similarly to IL-4, IL-13 has multiple effects on the differentiation and functions of monocytes/macrophages. IL-13 can suppress the cytotoxic functions of monocytes/macrophages. It can also suppress the production of proinflammatory cytokines and upregulate the production of IL-1ra by monocytes/macrophages.
Purity: >95% by SDS-PAGE and HPLC analyses
Formulation: Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.2.
Specific Activity: Fully biologically active when compared to standard. The ED50as determined by the dose-dependent proliferation of TF-1 cells was < 1.0 ng/ml, corresponding to a specific activity of > 1×106units/mg.
Endotoxin: Less than 1EU/mg of rHuIL-13 as determined by LAL method.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at<-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Gene Name: IL13
Synonyms: ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789; interleukin 13; IL13_HUMAN; Interleukin-13 [Precursor]; NC30; IL13; interleukin 13
Gene ID: 3596
mRNA Refseq: NM_002188
Protein Refseq: NP_002179
MIM: 147683
UniProt ID: P35225
Chromosome Location: 5q31
Pathway: Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Jak-STAT signaling pathway.
Function: interleukin-13 receptor binding;protein binding;signal transducer activity

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