Recombinant Human LIN28A, His-tagged

• Cat.No.: LIN28A-8467H
• Product Overview: Recombinant Human LIN28A, fused with His tag, was expressed in E. coli.

Specification

• Description: Lin28 is a RNA-binding protein that belongs to a diverse family of structurally-related transcription factors.Lin28 is found abundantly in embryonic stem cells (ESCs). and to a lesser extent in placenta and testis. Lin28 has been shown to block let-7 microRNA processing and maturation. a necessary step in the differentiation of stem cells and certain cancer cell lines. Together with Sox2. Oct4. and Nanog. Lin28 can induce the reprogramming of primary human fibroblasts to a pluripotent state. Lin28 and other regulatory proteins can be introduced into cells by DNA transfection. viral infection. or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing proteins into primary as well as transformed cells.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 20 mM Tris-Cl, pH 7.9, 20% Glycerol. 100 mM KCl. 1 mM DTT and 0.2 mM EDTA
• Molecular Mass: 22.7 kDa
• Endotoxin: Less than 1.0 EU/μg by LAL method
• Purity: >95% as determined by SDS-PAGE
• Storage: -80 °C
• Shipping: Dry Ice

Gene Information

• Gene Name: LIN28A lin-28 homolog A (C. elegans) [ Homo sapiens ]
• Official Symbol: LIN28A
• Synonyms: LIN28A; lin-28 homolog A (C. elegans); lin 28 homolog (C. elegans) , LIN28; protein lin-28 homolog A; CSDD1; FLJ12457; LIN 28; ZCCHC1; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1; zinc finger CCHC domain-containing protein 1; LIN28; LIN-28; lin-28A
• Gene ID: 79727
• mRNA Refseq: NM_024674
• Protein Refseq: NP_078950
• MIM: 611043
• UniProt ID: Q9H9Z2
• Chromosome Location: 1p35.3
• Function: DNA binding; RNA binding; mRNA binding; metal ion binding; miRNA binding; protein binding; translation initiation factor binding; zinc ion binding