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Recombinant Human LIN28A, His-tagged

Cat.No.: LIN28A-8467H
Product Overview: Recombinant Human LIN28A, fused with His tag, was expressed in E. coli.
Description: Lin28 is a RNA-binding protein that belongs to a diverse family of structurally-related transcription factors.Lin28 is found abundantly in embryonic stem cells (ESCs). and to a lesser extent in placenta and testis. Lin28 has been shown to block let-7 microRNA processing and maturation. a necessary step in the differentiation of stem cells and certain cancer cell lines. Together with Sox2. Oct4. and Nanog. Lin28 can induce the reprogramming of primary human fibroblasts to a pluripotent state. Lin28 and other regulatory proteins can be introduced into cells by DNA transfection. viral infection. or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing proteins into primary as well as transformed cells.
Source: E. coli
Species: Human
Tag: His
Form: 20 mM Tris-Cl, pH 7.9, 20% Glycerol. 100 mM KCl. 1 mM DTT and 0.2 mM EDTA
Molecular Mass: 22.7 kDa
Endotoxin: Less than 1.0 EU/μg by LAL method
Purity: >95% as determined by SDS-PAGE
Storage: -80 °C
Shipping: Dry Ice
Gene Name: LIN28A lin-28 homolog A (C. elegans) [ Homo sapiens ]
Official Symbol: LIN28A
Synonyms: LIN28A; lin-28 homolog A (C. elegans); lin 28 homolog (C. elegans) , LIN28; protein lin-28 homolog A; CSDD1; FLJ12457; LIN 28; ZCCHC1; RNA-binding protein LIN-28; zinc finger, CCHC domain containing 1; zinc finger CCHC domain-containing protein 1; LIN28; LIN-28; lin-28A;
Gene ID: 79727
mRNA Refseq: NM_024674
Protein Refseq: NP_078950
MIM: 611043
UniProt ID: Q9H9Z2
Chromosome Location: 1p35.3
Function: DNA binding; RNA binding; mRNA binding; metal ion binding; miRNA binding; protein binding; translation initiation factor binding; zinc ion binding;

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