Active Recombinant Human BCL10, His-tagged
Cat.No. : | BCL10-8496H |
Product Overview : | Recombinant Human BCL10, fused with His tag, was expressed in Sf21 Cells. |
- Specification
- Gene Information
- Related Products
Description : | Bcl-10 is an intracellular signaling protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas. The human Bcl10 gene encodes a protein of 233 amino acids containing an N-terminal caspase recruitment domain (CARD) that mediates self-oligomerization and the C-terminal region of Bcl-10. Bcl 10 is expressed ubiquitously with high expression levels in lymphoid tissues and in the developing central nerve system (4-6). Mutations have been found in cases of follicular lymphoma and diffuse large B cell lymphoma. Bcl-10 is a positive regulator of antigen-receptor induced NF-kB activation and Bcl-10-initiated activation of NF-kB can be inhibited by cotransfection of dominant-negative mutants of TRAF2, NIK, IKKa or IkBa (3-5, 8). |
Source : | Sf21 Cells |
Species : | Human |
Tag : | His |
Form : | 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA |
Bio-activity : | 1 unit equals 1 ng of purified protein. 100 units are required for a protein-protein interaction assay. |
AA Sequence : | MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS TVMYHPEGES STTPFFSTNS SLNLPVLEVG RTENTIFSST TLPRPGDPGA PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ |
Purity : | >95% as determined by SDS-PAGE |
Storage : | -80 °C |
Concentration : | 250 μg/ml |
Shipping : | Dry Ice |
Gene Name : | BCL10 B-cell CLL/lymphoma 10 [ Homo sapiens ] |
Official Symbol : | BCL10 |
Synonyms : | BCL10; B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; c E10; CARD containing molecule enhancing NF kB; CARD containing apoptotic signaling protein; CARD containing proapoptotic protein; CARD like apoptotic protein; CARMEN; caspase recruiting domain containing protein; CIPER; CLAP; mE10; hCLAP; cCARMEN; cellular-E10; cellular homolog of vCARMEN; CARD-containing proapoptotic protein; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; caspase-recruiting domain-containing protein; CARD-containing molecule enhancing NF-kappa-B; mammalian CARD-containing adapter molecule E10; CED-3/ICH-1 prodomain homologous E10-like regulator; c-E10; |
Gene ID : | 8915 |
mRNA Refseq : | NM_003921 |
Protein Refseq : | NP_003912 |
MIM : | 603517 |
UniProt ID : | O95999 |
Chromosome Location : | 1p22 |
Pathway : | Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; |
Function : | NF-kappaB binding; enzyme binding; contributes_to kinase activator activity; kinase binding; protease binding; protein C-terminus binding; protein binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding; |
Products Types
◆ Recombinant Protein | ||
Bcl10-555M | Recombinant Mouse Bcl10 Protein, His-tagged | +Inquiry |
BCL10-349R | Recombinant Rhesus Macaque BCL10 Protein, His (Fc)-Avi-tagged | +Inquiry |
BCL10-614R | Recombinant Rat BCL10 Protein, His (Fc)-Avi-tagged | +Inquiry |
BCL10-16H | Recombinant Human BCL10 Protein, His-tagged | +Inquiry |
BCL10-1016H | Active Recombinant Human B-cell CLL/lymphoma 10 | +Inquiry |
◆ Lysates | ||
BCL10-8490HCL | Recombinant Human BCL10 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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