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Native Human GPX1

Cat.No.: GPX1-8429H
Product Overview: Native Human GPX1 was purified from Erythrocytes.
Description: Peroxides in the cell can form highly reactive and damaging free radicals. Glutathione peroxidase (GPO) is a selenoenzyme with peroxidase activity, whose main biological purpose is the elimination of reactive oxygen species to protect the cell.
Source: Erythrocytes
Species: Human
Form: Frozen in 4.3mM sodium phosphate buffer, pH 7.0, containing 0.2mM DTT and sucrose at 0.25 mg/ml.
Unit Definition: One unit will catalyse oxidation by Hydrogen Peroxide of 1.0 micromole of reduced glutathione to oxidised glutathione per minute at pH 7.0 at 25°C.
Concentration: >30 U/mg
Reconstitution: Use of a 0.1M sodium acetate buffer pH 4.5 is recommended.
Gene Name: GPX1 glutathione peroxidase 1 [ Homo sapiens ]
Official Symbol: GPX1
Synonyms: GPX1; glutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase; GPXD; GSHPX1; MGC14399; MGC88245;
Gene ID: 2876
mRNA Refseq: NM_000581
Protein Refseq: NP_000572
MIM: 138320
UniProt ID: P07203
Chromosome Location: 3p21.3
Pathway: Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Folate Metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem;
Function: SH3 domain binding; endopeptidase inhibitor activity; glutathione peroxidase activity; glutathione peroxidase activity; oxidoreductase activity;

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