"IL2" Related Products

Recombinant Human Interleukin 2, His-tagged

Cat.No.: IL2-8861H
Product Overview: Recombinant Human Interleukin 2 was produced in the endosperm tissue of barley grain (Hordeum vulgare).
Description: Interleukin 2 (IL-2) is a potent immunoregulatory growth factor produced by T-cells following stimulation by mitogens or allogens. IL-2 promotes growth and differentiation of various cells of the immune system, such as activated T-cells and B-cells, NK cells, lymphokine activated killer cells, monocytes and macrophages. It is essential for proper immune response, it may also be an important factor in the natural suppression of autoimmunity. IL-2 may be of use as an anti-tumor agent in cancer therapy.
Source: Hordeum vulgare
Species: Human
Predicted N Terminal: His
Form: Sterile filtered through a 0.2 μm filter. Lyophilized from PBS, pH 7.2.
Bio-activity: Bioactivity of recombinant human IL-2 is assayed by measuring its dose dependent effect on proliferation of CTLL-2 cells. The ED50 for this effect is typically< 0.25 ng/ml, corresponding to a specific activity>4 x10e6 U/mg.
Molecular Mass: Recombinant human IL-2 contains 133 amino acids and a 16 a.a. histidine-based tag for a total length of 149 a.a. and has a predicted molecular mass of 17.5 kDa. The recombinant protein migrates with an apparent molecular mass of 22 kDa in SDS-PAGE.
Endotoxin: Endotoxin level is less than 0.05EU/μg as measured by turbidimetric kinetic assay.
Purity: >95% by SDS-PAGE gel analysis.
Storage: The lyophilized protein is stable at room temperature for few weeks. Reconstituted protein should be used immediately or stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 μg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Gene Name: IL2 interleukin 2 [ Homo sapiens ]
Official Symbol: IL2
Synonyms: IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; involved in regulation of T-cell clonal expansion; IL-2; lymphokine;
Gene ID: 3558
mRNA Refseq: NM_000586
Protein Refseq: NP_000577
MIM: 147680
UniProt ID: P60568
Chromosome Location: 4q26-q27
Pathway: Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;
Function: carbohydrate binding; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding; kinase activator activity;

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