Recombinant Human TNNI3, His-tagged


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Recombinant Human TNNI3, His-tagged

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Cat. No. : TNNI3-27665H
Product Overview : Recombinant Human TNNI3 was expressed as 6*his-tagged fusion protein by E.Coli and purified by Ni-sepharose.
Description : Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Source : E. coli
Antigen peptideregion : 1-110aa
Tag : His
Storagebuffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Storage : The protein is stored in PBS buffer at -20 oC. Repeated freezethaw cycles should be avoided.
OfficialSymbol : TNNI3
PDB rendering basedon 1j1d. :

Gene Name : TNNI3 troponin I type 3 (cardiac) [ Homo sapiens ]
Synonyms : TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; MGC116817; CMD1FF; troponin I, cardiac; Troponin I, cardiac muscle; Cardiac troponin I; familial hypertrophic cardiomyopathy 7
Gene ID : 7137
mRNA Refseq : NM_000363
Protein Refseq : NP_000354
MIM : 191044
UniProt ID : P19429
Chromosome Location : 19q13.4
Pathway : Hypertrophic cardiomyopathy (HCM); Muscle contraction; Cardiac muscle contraction
Function : actin binding; calcium-dependent protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding; calcium channel inhibitor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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