Recombinant Human TNNI3, His-tagged TNNI3-27665H

Recombinant Human TNNI3, His-tagged

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Recombinant Human TNNI3, His-tagged

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Cat. No. : TNNI3-27665H
Product Overview : Recombinant Human TNNI3 was expressed as 6*his-tagged fusion protein by E.Coli and purified by Ni-sepharose.
Description : Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Source : E. coli
Antigen peptideregion : 1-110aa
Tag : His
Storagebuffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Storage : The protein is stored in PBS buffer at -20 oC. Repeated freezethaw cycles should be avoided.
OfficialSymbol : TNNI3
PDB rendering basedon 1j1d. :

Gene Name : TNNI3 troponin I type 3 (cardiac) [ Homo sapiens ]
Synonyms : TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; MGC116817; CMD1FF; troponin I, cardiac; Troponin I, cardiac muscle; Cardiac troponin I; familial hypertrophic cardiomyopathy 7
Gene ID : 7137
mRNA Refseq : NM_000363
Protein Refseq : NP_000354
MIM : 191044
UniProt ID : P19429
Chromosome Location : 19q13.4
Pathway : Hypertrophic cardiomyopathy (HCM); Muscle contraction; Cardiac muscle contraction
Function : actin binding; calcium-dependent protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding; calcium channel inhibitor activity

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