Recombinant Human ADH1B, His-tagged
Cat.No. : | ADH1B-9417H |
Product Overview : | Recombinant Human ADH1B protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 1-375a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide [ Homo sapiens ] |
Official Symbol : | ADH1B |
Synonyms : | ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide; ADH2; alcohol dehydrogenase 1B; ADH, beta subunit; aldehyde reductase; alcohol dehydrogenase subunit beta; alcohol dehydrogenase 2 (class I), beta polypeptide; |
Gene ID : | 125 |
mRNA Refseq : | NM_000668 |
Protein Refseq : | NP_000659 |
UniProt ID : | P00325 |
Chromosome Location : | 4q23 |
Pathway : | Biological oxidations, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem; Drug metabolism - cytochrome P450, conserved biosystem; Ethanol oxidation, organism-specific biosystem; Fatty Acid Omega Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem; |
Function : | alcohol dehydrogenase activity, zinc-dependent; metal ion binding; nucleotide binding; oxidoreductase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
ADH1B-74R | Recombinant Rhesus Macaque ADH1B Protein, His (Fc)-Avi-tagged | +Inquiry |
ADH1B-0248H | Recombinant Human ADH1B Protein (S2-F375), Tag Free | +Inquiry |
ADH1B-29C | Recombinant Cynomolgus Monkey ADH1B Protein, His (Fc)-Avi-tagged | +Inquiry |
ADH1B-283H | Recombinant Human ADH1B Protein, His (Fc)-Avi-tagged | +Inquiry |
ADH1B-0249H | Recombinant Human ADH1B Protein (S2-F375), GST tagged | +Inquiry |
◆ Lysates | ||
ADH1B-9014HCL | Recombinant Human ADH1B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (10)
Ask a questionADH1B deficiency or knockout in experimental models leads to altered alcohol metabolism and related phenotypes, such as decreased alcohol clearance and increased sensitivity to alcohol-induced effects.
ADH1B plays a significant role in alcohol metabolism, showing specific catalytic efficiency and substrate specificity for the conversion of alcohol to acetaldehyde.
Pharmacological agents or environmental factors can modulate ADH1B expression or activity, potentially influencing alcohol metabolism and providing avenues for therapeutic interventions or personalized medicine.
Genetic variations or polymorphisms in the ADH1B gene have been associated with differences in alcohol metabolism and susceptibility to alcohol-related disorders, highlighting the impact of genotype on phenotype.
ADH1B has the capacity to metabolize other substrates beyond alcohol, suggesting its involvement in broader metabolic pathways and potential metabolic interactions.
ADH1B expression or activity may vary among different species or populations, influenced by genetic and environmental factors, contributing to inter-individual or inter-species differences in alcohol metabolism and tolerance.
ADH1B exhibits a tissue-specific expression pattern, with higher expression levels in certain organs such as the liver, and its distribution may differ from other ADH isoforms, reflecting functional specialization.
The structural features of ADH1B, such as its active site and binding domains, are critical for its enzymatic activity and substrate recognition, enabling efficient alcohol oxidation.
There may be interacting proteins or partners of ADH1B that influence its function or localization, potentially modulating its enzymatic activity or cellular processes.
The expression of ADH1B is regulated by specific mechanisms, including transcriptional and post-transcriptional regulation, which can respond to alcohol exposure or metabolic factors such as hormonal signaling.
Customer Reviews (2)
Write a reviewShows outstanding biocompatibility and low cytotoxicity in cell culture experiments.
Displays excellent resistance to denaturation by chaotropic agents in stability assays.
Ask a Question for All ADH1B Products
Required fields are marked with *
My Review for All ADH1B Products
Required fields are marked with *
Inquiry Basket