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Recombinant Human ADH1B, His-tagged

Cat.No. : ADH1B-9417H
Product Overview : Recombinant Human ADH1B protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
Source : E.coli
Species : Human
Tag : His
Protein length : 1-375a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide [ Homo sapiens ]
Official Symbol : ADH1B
Synonyms : ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide; ADH2; alcohol dehydrogenase 1B; ADH, beta subunit; aldehyde reductase; alcohol dehydrogenase subunit beta; alcohol dehydrogenase 2 (class I), beta polypeptide;
Gene ID : 125
mRNA Refseq : NM_000668
Protein Refseq : NP_000659
UniProt ID : P00325
Chromosome Location : 4q23
Pathway : Biological oxidations, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem; Drug metabolism - cytochrome P450, conserved biosystem; Ethanol oxidation, organism-specific biosystem; Fatty Acid Omega Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem;
Function : alcohol dehydrogenase activity, zinc-dependent; metal ion binding; nucleotide binding; oxidoreductase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What are the consequences of ADH1B deficiency or knockout in experimental models, and how does it affect alcohol metabolism and related phenotypes? 09/21/2021

ADH1B deficiency or knockout in experimental models leads to altered alcohol metabolism and related phenotypes, such as decreased alcohol clearance and increased sensitivity to alcohol-induced effects.

How does ADH1B contribute to alcohol metabolism, and what is its catalytic efficiency and substrate specificity compared to other ADH isoforms? 07/22/2020

ADH1B plays a significant role in alcohol metabolism, showing specific catalytic efficiency and substrate specificity for the conversion of alcohol to acetaldehyde.

How does the expression or activity of ADH1B change in response to pharmacological agents or environmental factors, and what are the implications for alcohol metabolism or therapy? 06/20/2020

Pharmacological agents or environmental factors can modulate ADH1B expression or activity, potentially influencing alcohol metabolism and providing avenues for therapeutic interventions or personalized medicine.

Are there any known genetic variations or polymorphisms in the ADH1B gene associated with differences in alcohol metabolism or susceptibility to alcohol-related disorders? 01/06/2020

Genetic variations or polymorphisms in the ADH1B gene have been associated with differences in alcohol metabolism and susceptibility to alcohol-related disorders, highlighting the impact of genotype on phenotype.

Can ADH1B metabolize other substrates apart from alcohol, and what are the implications for its broader metabolic role? 08/24/2019

ADH1B has the capacity to metabolize other substrates beyond alcohol, suggesting its involvement in broader metabolic pathways and potential metabolic interactions.

How does ADH1B expression or activity vary in different species or populations, and what are the underlying genetic and environmental factors influencing these variations? 06/24/2019

ADH1B expression or activity may vary among different species or populations, influenced by genetic and environmental factors, contributing to inter-individual or inter-species differences in alcohol metabolism and tolerance.

What is the tissue-specific expression pattern of ADH1B, and how does it differ from other ADH isoforms in terms of its expression levels and distribution across organs and cell types? 01/02/2019

ADH1B exhibits a tissue-specific expression pattern, with higher expression levels in certain organs such as the liver, and its distribution may differ from other ADH isoforms, reflecting functional specialization.

What are the structural features of ADH1B, and how do they relate to its enzymatic activity and substrate binding? 06/26/2018

The structural features of ADH1B, such as its active site and binding domains, are critical for its enzymatic activity and substrate recognition, enabling efficient alcohol oxidation.

Are there any interacting proteins or partners of ADH1B that influence its function or localization? 05/30/2017

There may be interacting proteins or partners of ADH1B that influence its function or localization, potentially modulating its enzymatic activity or cellular processes.

What are the regulatory mechanisms controlling ADH1B expression, and how do they respond to alcohol exposure or other metabolic factors? 03/19/2017

The expression of ADH1B is regulated by specific mechanisms, including transcriptional and post-transcriptional regulation, which can respond to alcohol exposure or metabolic factors such as hormonal signaling.

Customer Reviews (2)

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08/25/2022

    Shows outstanding biocompatibility and low cytotoxicity in cell culture experiments.

    04/03/2019

      Displays excellent resistance to denaturation by chaotropic agents in stability assays.

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