"Il15" Related Products

Expand
Expand

Recombinant Mouse Interleukin 15

Cat. No.: Il15-69M
Product Overview: Recombinant Mouse Interleukin-15 produced inE.Coliis a single, non-glycosylated polypeptide chain containing 115 amino acids and having a molecular mass of 13321 Dalton. The IL-15 is purified by proprietary chromatographic techniques.
Description: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other"s activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
Source: Escherichia Coli.
Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Met-Asn-Trp-Ile-Asp.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 98% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: The protein was lyophilized from a concentrated (1mg/ml) solution with 10mM NaP pH 8.0.
Solubility: It is recommended to reconstitute the lyophilized Interleukin-15 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity: The ED50as determined by the dose-dependant stimulation of the proliferation of mouse CTLL-2 was found to be 15 ng/ml, corresponding to a Specific Activity of 2 x 105 IU/mg.
Storage: Lyophilized Interleukin-15 although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution IL15 should be stored at 4℃between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles
Gene Name: Il15 interleukin 15 [ Mus musculus ]
Synonyms: Il15; interleukin 15; AI503618
Gene ID: 16168
mRNA Refseq: NM_008357
Protein Refseq: NP_032383
UniProt ID: P48346
Chromosome Location: 8 C2; 8 38.0 cM
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokine activity; cytokine receptor binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.