"BCL6" Related Products


Recombinant Human BCL6, GST-tagged

Cat.No.: BCL6-10185H
Product Overview: Recombinant Human BCL6 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 183-532a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ]
Official Symbol: BCL6
Synonyms: BCL6; B-cell CLL/lymphoma 6; zinc finger protein 51 , ZNF51; B-cell lymphoma 6 protein; BCL5; BCL6A; LAZ3; ZBTB27; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; ZNF51;
Gene ID: 604
mRNA Refseq: NM_001130845
Protein Refseq: NP_001124317
MIM: 109565
UniProt ID: P41182
Chromosome Location: 3q27
Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;
Function: chromatin DNA binding; chromatin binding; metal ion binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding;

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