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Recombinant Human CA4, GST-tagged

Cat.No.: CA4-10621H
Product Overview: Recombinant Human CA4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport.
Source: E.coli
Species: Human
Tag: GST
Protein length: 16-281a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: CA4 carbonic anhydrase IV [ Homo sapiens ]
Official Symbol: CA4
Synonyms: CA4; carbonic anhydrase IV; retinitis pigmentosa 17 (autosomal dominant) , RP17; carbonic anhydrase 4; CAIV; Car4; CA-IV; carbonic dehydratase IV; carbonate dehydratase IV; RP17;
Gene ID: 762
mRNA Refseq: NM_000717
Protein Refseq: NP_000708
MIM: 114760
UniProt ID: P22748
Chromosome Location: 17q23
Pathway: Proximal tubule bicarbonate reclamation, organism-specific biosystem; Proximal tubule bicarbonate reclamation, conserved biosystem;
Function: carbonate dehydratase activity; lyase activity; metal ion binding; protein binding; zinc ion binding;

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