Recombinant Human CA5B, GST-tagged
Cat.No. : | CA5B-10623H |
Product Overview : | Recombinant Human CA5B protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-317a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | CA5B carbonic anhydrase VB, mitochondrial [ Homo sapiens ] |
Official Symbol : | CA5B |
Synonyms : | CA5B; carbonic anhydrase VB, mitochondrial; carbonic anhydrase 5B, mitochondrial; carbonic dehydratase; carbonate dehydratase VB; CA-VB; MGC39962; |
Gene ID : | 11238 |
mRNA Refseq : | NM_007220 |
Protein Refseq : | NP_009151 |
MIM : | 300230 |
UniProt ID : | Q9Y2D0 |
Chromosome Location : | Xp22.1 |
Function : | carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding; |
Products Types
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CA5B-2267H | Recombinant Human CA5B Protein, MYC/DDK-tagged | +Inquiry |
CA5B-0243H | Recombinant Human CA5B Protein, GST-Tagged | +Inquiry |
CA5b-720R | Recombinant Rat CA5b Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CA5B-265HCL | Recombinant Human CA5B cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMutations might influence CA5B's enzymatic activity or protein stability, requiring comparative functional assays.
CA5B aids in the reversible conversion of CO2 to bicarbonate and protons, essential for pH regulation and CO2 transport within cells.
CA5B's post-translational modifications can be detected using mass spectrometry, with potential sites for phosphorylation or other modifications.
Abnormal CA5B function or expression could impact metabolic homeostasis in tissues, potentially contributing to metabolic or neurological disorders.
CA5B is prominently expressed in the mitochondria of various tissues, including skeletal muscle and the brain.
CA5B operates within mitochondrial environments, which may lead to specific enzymatic kinetics compared to cytosolic isoforms.
General carbonic anhydrase inhibitors might affect CA5B, but specific inhibitors for CA5B would need exploration.
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