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Recombinant Human CA5B, GST-tagged

Cat.No. : CA5B-10623H
Product Overview : Recombinant Human CA5B protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-317a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : CA5B carbonic anhydrase VB, mitochondrial [ Homo sapiens ]
Official Symbol : CA5B
Synonyms : CA5B; carbonic anhydrase VB, mitochondrial; carbonic anhydrase 5B, mitochondrial; carbonic dehydratase; carbonate dehydratase VB; CA-VB; MGC39962;
Gene ID : 11238
mRNA Refseq : NM_007220
Protein Refseq : NP_009151
MIM : 300230
UniProt ID : Q9Y2D0
Chromosome Location : Xp22.1
Function : carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do mutations in the CA5B gene potentially affect the protein's enzymatic function? 05/09/2022

Mutations might influence CA5B's enzymatic activity or protein stability, requiring comparative functional assays.

How does CA5B participate in cellular pH regulation and metabolism? 03/31/2020

CA5B aids in the reversible conversion of CO2 to bicarbonate and protons, essential for pH regulation and CO2 transport within cells.

What specific post-translational modifications are associated with CA5B? 11/12/2019

CA5B's post-translational modifications can be detected using mass spectrometry, with potential sites for phosphorylation or other modifications.

Are there any specific diseases or conditions linked with aberrant CA5B expression or function? 03/17/2018

Abnormal CA5B function or expression could impact metabolic homeostasis in tissues, potentially contributing to metabolic or neurological disorders.

Which human tissues or organs display the most significant expression of CA5B? 03/31/2017

CA5B is prominently expressed in the mitochondria of various tissues, including skeletal muscle and the brain.

How does the enzymatic function of CA5B distinguish it from other carbonic anhydrase isoforms? 03/06/2017

CA5B operates within mitochondrial environments, which may lead to specific enzymatic kinetics compared to cytosolic isoforms.

Are there any known direct inhibitors targeting CA5B's enzymatic activity? 01/22/2017

General carbonic anhydrase inhibitors might affect CA5B, but specific inhibitors for CA5B would need exploration.

Customer Reviews (3)

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10/23/2022

    Dependable source for all research-related necessities.

    01/02/2021

      Professional support team, quick to respond and assist.

      12/14/2020

        Precision in protein characterization, unmatched excellence.

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