Recombinant Human CENPH, His-tagged CENPH-11095H

Recombinant Human CENPH, His-tagged


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Recombinant Human CENPH, His-tagged

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Cat.No. : CENPH-11095H
Product Overview : Recombinant Human CENPH protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulaton of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1.
Source : E.coli
Species : Human
Tag : His
Protein length : 1-247a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : CENPH centromere protein H [ Homo sapiens ]
Official Symbol : CENPH
Synonyms : CENPH; centromere protein H; NNF1; MIND kinetochore complex component; homolog (S. cerevisiae); PMF1; CENP-H; kinetochore protein CENP-H; interphase centromere complex protein 35;
Gene ID : 64946
mRNA Refseq : NM_022909
Protein Refseq : NP_075060
MIM : 605607
UniProt ID : Q9H3R5
Chromosome Location : 5p15.2
Pathway : Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem; DNA Replication, organism-specific biosystem; Deposition of New CENPA-containing Nucleosomes at the Centromere, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem;
Function : kinetochore binding; protein binding;

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