Recombinant Human DAAM1, GST-tagged

• Cat.No.: DAAM1-11811H
• Product Overview: Recombinant Human DAAM1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 715-1068a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DAAM1 dishevelled associated activator of morphogenesis 1 [ Homo sapiens ]
• Official Symbol: DAAM1
• Synonyms: DAAM1; dishevelled associated activator of morphogenesis 1; disheveled-associated activator of morphogenesis 1; KIAA0666; FLJ41657
• Gene ID: 23002
• mRNA Refseq: NM_014992
• Protein Refseq: NP_055807
• MIM: 606626
• UniProt ID: Q9Y4D1
• Chromosome Location: 14q22.3
• Pathway: Noncanonical Wnt signaling pathway, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem
• Function: Rho GTPase binding; actin binding; binding