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Recombinant Human DNASE1, GST-tagged

Cat.No.: DNASE1-12094H
Product Overview: Recombinant Human DNASE1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-282a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: DNASE1 deoxyribonuclease I [ Homo sapiens ]
Official Symbol: DNASE1
Synonyms: DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; DNase I, lysosomal; human urine deoxyribonuclease I; DRNI; FLJ38093; FLJ44902; DKFZp686H0155;
Gene ID: 1773
mRNA Refseq: NM_005223
Protein Refseq: NP_005214
MIM: 125505
UniProt ID: P24855
Chromosome Location: 16p13.3
Function: actin binding; deoxyribonuclease I activity; deoxyribonuclease activity; endonuclease activity; hydrolase activity; protein binding;

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