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Recombinant Human ENO1, His-tagged

Cat.No. : ENO1-12451H
Product Overview : Recombinant Human ENO1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.
Source : E.coli
Species : Human
Tag : His
Protein length : 1-433a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ENO1 enolase 1, (alpha) [ Homo sapiens ]
Official Symbol : ENO1
Synonyms : ENO1; enolase 1, (alpha); ENO1L1, MPB1; alpha-enolase; c-myc promoter-binding protein-1; MBP 1; PPH; alpha-enolase; enolase-alpha; tau-crystallin; non-neural enolase; alpha enolase like 1; phosphopyruvate hydratase; plasminogen-binding protein; MYC promoter-binding protein 1; 2-phospho-D-glycerate hydro-lyase; NNE; MPB1; ENO1L1;
Gene ID : 2023
mRNA Refseq : NM_001201483
Protein Refseq : NP_001188412
MIM : 172430
UniProt ID : P06733
Chromosome Location : 1p36.2
Pathway : Gluconeogenesis, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystem; Glucose metabolism, organism-specific biosystem; Glycolysis, organism-specific biosystem;
Function : DNA binding; lyase activity; magnesium ion binding; phosphopyruvate hydratase activity; protein binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What are some of the cancers where ENO1 is overexpressed? 11/26/2022

ENO1 overexpression is seen in cancers like lung cancer, breast cancer, pancreatic cancer, and glioblastoma, among others.

Are there any diagnostic or therapeutic applications for ENO1 in infectious diseases? 04/17/2021

ENO1 in infectious agents may offer potential targets for diagnostic tests and treatments, although this field of research is still developing.

Are there any targeted therapies that focus on ENO1 in cancer treatment? 12/21/2018

Some research suggests that targeted therapies directed at ENO1 could be a potential strategy for cancer treatment, but more studies are needed.

Can ENO1 be used as a diagnostic marker for autoimmune diseases? 11/29/2016

ENO1 antibodies can be used as diagnostic markers for autoimmune diseases like celiac disease.

Are there diagnostic applications for ENO1 in neurodegenerative diseases? 10/09/2016

ENO1 may serve as a potential biomarker for the early diagnosis and monitoring of neurodegenerative diseases, although more research is needed.

Customer Reviews (3)

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07/24/2021

    Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

    03/30/2021

      the use of ENO1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

      06/25/2020

        The manufacturer of ENO1 protein plays a crucial role in supporting my research endeavors.

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