"ERCC8" Related Products


Recombinant Human ERCC8, His-tagged

Cat.No.: ERCC8-12527H
Product Overview: Recombinant Human ERCC8 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Source: E.coli
Species: Human
Tag: His
Protein length: 1-205a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 [ Homo sapiens ]
Official Symbol: ERCC8
Synonyms: ERCC8; excision repair cross-complementing rodent repair deficiency, complementation group 8; CKN1, Cockayne syndrome 1 (classical); DNA excision repair protein ERCC-8; CSA; Cockayne syndrome WD-repeat protein CSA; cockayne syndrome WD repeat protein CSA; CKN1;
Gene ID: 1161
mRNA Refseq: NM_000082
Protein Refseq: NP_000073
MIM: 609412
UniProt ID: Q13216
Chromosome Location: 5q12.1
Pathway: Cul4-DDB1-CSA complex, organism-specific biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Formation of transcription-coupled NER (TC-NER) repair complex, organism-specific biosystem; Nucleotide Excision Repair, organism-specific biosystem; Nucleotide excision repair, organism-specific biosystem; Nucleotide excision repair, conserved biosystem;
Function: NOT DNA helicase activity; NOT DNA-dependent ATPase activity; protein binding; protein complex binding; contributes_to ubiquitin-protein ligase activity;

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