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Recombinant Rat Ltbr, Fc tagged

Cat.No. : LTBR-380R
Product Overview : Recombinant Rat Ltbr (Q5U2S8) (Met1-Ala218), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cells.
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  • Gene Information
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Source : Human Cells
Species : Rat
Tag : Fc
Predicted N Terminal : Ser 28
Form : Lyophilized from sterile PBS, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The recombinant rat LTBR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 432 amino acids and has a predicted molecular mass of 48.5 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing condit
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : (9.8+79.7) % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) [ Rattus norvegicus ]
Official Symbol : Ltbr
Gene ID : 297604
mRNA Refseq : NM_001008315
Protein Refseq : NP_001008316

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What therapeutic strategies can be employed to target LTBR? 12/18/2022

Therapeutic strategies targeting LTBR include inhibition of its signaling pathways, modulation of immune response, and anti-cancer approaches. Inhibitors of the NF-κB pathway, such as small molecule inhibitors or neutralizing antibodies, can be used to block LTBR-mediated signaling and reduce inflammation or tumor growth.

What is the current research focus regarding the role of LTBR in disease mechanisms? 11/12/2021

Current research on LTBR aims to further elucidate its role in disease mechanisms, particularly in autoimmune disorders, chronic inflammation, and cancer. Studies are investigating the downstream effects of LTBR activation, its involvement in immune cell function, and the identification of potential therapeutic targets within the LTBR signaling pathway.

How is the expression of LTBR regulated at the transcriptional level? 06/26/2021

The expression of LTBR is regulated by transcription factors and signaling pathways. For example, NF-κB and AP-1 transcription factors can bind to the promoter region of LTBR gene and enhance its expression. Additionally, cytokines and growth factors can also influence LTBR expression through downstream signaling cascades.

How does the LTBR signaling pathway interact with other signaling pathways? 07/18/2020

The LTBR signaling pathway interacts with various other signaling pathways, including those activated by TNFR1, TNFR2, and CD40. These interactions can lead to crosstalk and amplification of signaling, resulting in enhanced cellular responses. Understanding these interactions is crucial for elucidating the complex network of signaling events involved in disease pathogenesis.

What is the biological function of LTBR and its involvement in cellular processes? 04/13/2018

LTBR, a membrane protein belonging to the tumor necrosis factor receptor superfamily, regulates various cellular processes such as inflammation, immune response, and lymphoid organ development. It activates signaling pathways including the NF-κB pathway and non-canonical NF-κB pathway.

Are there any genetic variants associated with LTBR expression and disease susceptibility? 01/06/2017

Yes, certain genetic variants have been identified that are associated with altered LTBR expression and disease susceptibility. These variants can affect the binding of transcription factors or alter the stability of LTBR mRNA, leading to dysregulation of LTBR expression and increased risk of certain diseases.

What are the potential future directions in LTBR research? 11/21/2016

Future research directions in LTBR include exploring the molecular mechanisms underlying LTBR-mediated signaling, investigating the impact of LTBR genetic variants on disease susceptibility, and developing novel therapeutic strategies targeting LTBR. Additionally, studying the interplay between LTBR and other signaling pathways may uncover new insights into disease pathogenesis and identify new therapeutic avenues.

Customer Reviews (3)

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Reviews
04/20/2020

    Unrivaled in efficiency, this innovative elixir leaves me awestruck.

    12/31/2019

      By using this reagent, I can better investigate protein interactions.

      02/09/2018

        The interpretation of the results provided by this reagent is clear, allowing me to better understand the experimental outcomes.

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