"SOCS3" Related Products

Expand
Expand
Expand

Recombinant Human SOCS3, His-tagged

Cat.No.: SOCS3-5093H
Product Overview: Recombinant human SOCS3 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Description: SOCS3 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of SOCS3 is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. This protein can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Molecular Mass: 29 kDa (262aa)
AA Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMVT HSKFPAAGMS RPLDTSLRLK TFSSKSEYQL VVNAVRKLQE SGFYWSAVTG GEANLLLSAE PAGTFLIRDS SDQRHFFTLS VKTQSGTKNL RIQCEGGSFS LQSDPRSTQP VPRFDCVLKL VHHYMPPPGA PSFPSPPTEP SSEVPEQPSA QPLPGSPPRR AYYIYSGGEK IPLVLSRPLS SNVATLQHLC RKTVNGHLDS YEKVTQLPGP IREFLDQYDA PL
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 0.5 mg/ml (determined by Bradford assay)
Gene Name: SOCS3 suppressor of cytokine signaling 3 [ Homo sapiens ]
Official Symbol: SOCS3
Synonyms: SOCS3; suppressor of cytokine signaling 3; CIS3; Cish3; SOCS 3; SSI 3; CIS-3; STAT-induced STAT inhibitor 3; cytokine-induced SH2 protein 3; cytokine-inducible SH2 protein 3; SSI3; ATOD4; SSI-3; SOCS-3; MGC71791;
Gene ID: 9021
mRNA Refseq: NM_003955
Protein Refseq: NP_003946
MIM: 604176
UniProt ID: O14543
Chromosome Location: 17q25.3
Pathway: ATF-2 transcription factor network, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem;
Function: protein kinase inhibitor activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.