- Human(14)
Recombinant Human CCL14 protein
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Cat.No. : | CCL14-607H |
Product Overview : | Recombinant Human CCL14 protein (66 a.a.) was expressed in Escherichia coli. |
Description : | Human CCL14 is belonging to the CC chemokine family. It is encoded by the gene CCL14. CCL14 has two isoforms, CCL14a (HCC-1) and CCL14b (HCC-3). The sequence of HCC-3 differs from HCC-1 as follow: 27-27 R→ QTGGKPKVVKIQLKLVG. CCL14 was first isolated from the hemofiltrate of human patients with chronic renal failure. The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. CCL14 promotes chemotaxis of T lymphocytes, monocytes and eosinophils, and inhibits infection of M-tropic human immunodeficiency virus type 1 and is a ligand for CCR1, CCR3 and CCR5. Recombinant human CCL14 (66 a.a.) contains 66 amino acid residues and activation of the HCC 1/CCL14a precursor to active peptide is mediated by the urokinase type plasminogen activator or plasmin. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in 2 × PBS, pH 7.4, 5 % trehalose. |
Bio-activity : | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 5.0-20 ng/ml. |
Molecular Mass : | Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 66 amino acids. |
Protein length : | 66 |
AA Sequence : | GPYHPSECCF TYTTYKIPRQ RIMDYYETNS QCSKPGIVFI TKRGHSVCTN PSDKWVQDYI KDMKEN |
Endotoxin : | Less than 1 EU/μg of rHuHCC-1, 66a.a./CCL14 as determined by LAL method. |
Purity : | >95% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | CCL14 |
Official Symbol : | CCL14 |
Synonyms : | CCL14; chemokine (C-C motif) ligand 14; SCYA14, small inducible cytokine subfamily A (Cys Cys), member 14; C-C motif chemokine 14; CKb1; HCC 1; HCC 3; MCIF; NCC 2; SCYL2; chemokine CC-3; new CC chemokine 2; chemokine CC-1/CC-3; hemofiltrate CC chemokine 1; small-inducible cytokine A14; small inducible cytokine subfamily A (Cys-Cys), member 14; CC-1; CC-3; CKB1; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYA14; HCC-1(1-74); HCC-1/HCC-3; FLJ16015; |
Gene ID : | 6358 |
mRNA Refseq : | NM_032962 |
Protein Refseq : | NP_116738 |
MIM : | 601392 |
UniProt ID : | Q16627 |
◆ Recombinant Protein
CCL14-0609H | Recombinant Human CCL14 Protein, GST-Tagged | +Inquiry |
CCL14-1527H | Recombinant Human CCL14 protein, His & GST-tagged | +Inquiry |
CCL14-10836H | Recombinant Human CCL14, GST-tagged | +Inquiry |
CCL14-335H | Recombinant Human Chemokine (C-C Motif) Ligand 14, HIgG1 Fc-tagged | +Inquiry |
CCL14-334H | Recombinant Human Chemokine (C-C Motif) Ligand 14, MIgG2a Fc-tagged | +Inquiry |
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◆ Lysates
CCL14-7732HCL | Recombinant Human CCL14 293 Cell Lysate | +Inquiry |
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CCL1 CCL11 Ccl12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 Ccl21c CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 Ccl27a CCL28 CCL3 CCL3L1 Ccl4 CCL5 Ccl6 CCL7 CCL8 Ccl9 CCL4L2 Ccl21a CCL4L1 CCL3L3 Ccl21b Ccl27b
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