- Human(10)
Recombinant Human CCL14 protein
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| Cat.No. : | CCL14-607H |
| Product Overview : | Recombinant Human CCL14 protein (66 a.a.) was expressed in Escherichia coli. |
| Description : | Human CCL14 is belonging to the CC chemokine family. It is encoded by the gene CCL14. CCL14 has two isoforms, CCL14a (HCC-1) and CCL14b (HCC-3). The sequence of HCC-3 differs from HCC-1 as follow: 27-27 R→ QTGGKPKVVKIQLKLVG. CCL14 was first isolated from the hemofiltrate of human patients with chronic renal failure. The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. CCL14 promotes chemotaxis of T lymphocytes, monocytes and eosinophils, and inhibits infection of M-tropic human immunodeficiency virus type 1 and is a ligand for CCR1, CCR3 and CCR5. Recombinant human CCL14 (66 a.a.) contains 66 amino acid residues and activation of the HCC 1/CCL14a precursor to active peptide is mediated by the urokinase type plasminogen activator or plasmin. |
| Source : | E.coli |
| Species : | Human |
| Form : | Lyophilized from a 0.2μm filtered concentrated solution in 2 × PBS, pH 7.4, 5 % trehalose. |
| Bio-activity : | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 5.0-20 ng/ml. |
| Molecular Mass : | Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 66 amino acids. |
| Protein length : | 66 |
| AA Sequence : | GPYHPSECCFTYTTY KIPRQRIMDYYETNS QCSKPGIVFITKRGH SVCTNPSDKWVQDYI KDMKEN |
| Endotoxin : | Less than 1 EU/μg of rHuHCC-1, 66a.a./CCL14 as determined by LAL method. |
| Purity : | >95% by SDS-PAGE and HPLC analysis. |
| Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
| Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
| Gene Name : | CCL14 |
| Official Symbol : | CCL14 |
| Synonyms : | CCL14; chemokine (C-C motif) ligand 14; SCYA14, small inducible cytokine subfamily A (Cys Cys), member 14; C-C motif chemokine 14; CKb1; HCC 1; HCC 3; MCIF; NCC 2; SCYL2; chemokine CC-3; new CC chemokine 2; chemokine CC-1/CC-3; hemofiltrate CC chemokine 1; small-inducible cytokine A14; small inducible cytokine subfamily A (Cys-Cys), member 14; CC-1; CC-3; CKB1; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYA14; HCC-1(1-74); HCC-1/HCC-3; FLJ16015; |
| Gene ID : | 6358 |
| mRNA Refseq : | NM_032962 |
| Protein Refseq : | NP_116738 |
| MIM : | 601392 |
| UniProt ID : | Q16627 |
◆ Recombinant Protein
| CCL14-0609H | Recombinant Human CCL14 Protein, GST-Tagged | +Inquiry |
| CCL14-0608H | Recombinant Human CCL14 protein | +Inquiry |
| CCL14-033H | Recombinant Human CCL14 Protein, His-tagged | +Inquiry |
| CCL14-10836H | Recombinant Human CCL14, GST-tagged | +Inquiry |
| CCL14-1527H | Recombinant Human CCL14 protein, His & GST-tagged | +Inquiry |
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◆ Lysates
| CCL14-7732HCL | Recombinant Human CCL14 293 Cell Lysate | +Inquiry |
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CCL1CCL11Ccl12CCL13CCL14CCL15CCL16CCL17CCL18CCL19CCL2CCL20CCL21Ccl21cCCL22CCL23CCL24CCL25CCL26CCL27Ccl27aCCL28CCL3CCL3L1Ccl4CCL5Ccl6CCL7CCL8Ccl9CCL4L2Ccl21aCCL4L1CCL3L3Ccl21bCcl27b
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