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Recombinant Rat Ccl7

Cat.No.: Ccl7-635R
Product Overview: Recombinant Rat Ccl7 produced in E. coli is approximately 8.4 kDa, a single, non-glycosylated polypeptide chain containing 74 amino acids.
Description: Monocyte Chemotactic Protein-3 (MCP3) and CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma cells. Both MCP3 and CCL7 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP1. CCL7 also shares 58% amino acid identity with MCP3. Similarly to other CC chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.
Source: E. coli
Species: Rat
Form: Lyophilized from a 0.2 μm filtered concentrated solution in 2× PBS, pH 7.4.
Bio-activity: Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human monocytes is in a concentration range of 100-300 ng/ml.
Molecular Mass: 8.4 kDa
AA Sequence: QPDGTNSSTC CYVKKQKIPK RNLKSYRKIT SSRCPWEAVI FKTKKGMEVC AEAHQKWVEE AIAYLDMKTS TPKP
Endotoxin: Less than 1 EU/μg of rHuRtMCP-3/CCL7 as determined by LAL method.
Purity: >95% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: Ccl7 chemokine (C-C motif) ligand 7 [ Rattus norvegicus ]
Official Symbol: Ccl7
Synonyms: CCL7; chemokine (C-C motif) ligand 7; C-C motif chemokine 7; MCP-3; chemotactic protein-3; small-inducible cytokine A7; monocyte chemotactic protein 3; monocyte chemoattractant protein 3;
Gene ID: 287561
mRNA Refseq: NM_001007612
Protein Refseq: NP_001007613
Pathway: Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem;
Function: CCR1 chemokine receptor binding; CCR2 chemokine receptor binding; CCR2 chemokine receptor binding; chemokine activity; chemokine activity; heparin binding;

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