"IHH" Related Products

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Recombinant Human IHH

Cat.No.: IHH-656H
Product Overview: Recombinant Human IHH produced in E. coli is approximately 19.8 kDa, a single non-glycosylated polypeptide chain containing 176 amino acids.
Description: IHH, encoded by the IHH gene in humans, belongs to the mammalian hedgehog family. It is expressed in adult kidney and liver. The function of IHH is involved in chondrocyte differentiation, proliferation and maturation especially during endochondral ossification. It regulates its effects by feedback control of parathyroid hormone-related peptide (PTHrP). IHH is also involved in yolk sac vasculogenesis, playing an important role in differentiation of epiblast cells into endothelial and red blood cells. Human IHH shares 100 % amino acid sequence identity with murine.
Source: E. coli
Species: Human
Form: Lyophilized from a 0.2 μm filtered concentrated solution in 1 × PBS, pH 7.4.
Bio-activity: Fully biologically active when compared to standard. The ED 50 determined by its ability to induce alkaline phosphatase production by C3H10T1/2(CCL-226) cells is 3.0-10 μg/ml.
Molecular Mass: 19.8 kDa
AA Sequence: IIGPGRVVGS RRRPPRKLVP LAYKQFSPNV PEKTLGASGR YEGKIARSSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDRLNSLAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRNKYGLL ARLAVEAGFD WVYYESKAHV HCSVKSEHSA AAKTGG
Endotoxin: Less than 1 EU/μg of rHuIHH C28II as determined by LAL method.
Purity: >96% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: IHH Indian hedgehog [ Homo sapiens ]
Official Symbol: IHH
Synonyms: IHH; Indian hedgehog; Indian hedgehog (Drosophila) homolog , Indian hedgehog homolog (Drosophila); indian hedgehog protein; BDA1; HHG2; HHG-2; Indian hedgehog homolog;
Gene ID: 3549
mRNA Refseq: NM_002181
Protein Refseq: NP_002172
MIM: 600726
UniProt ID: Q14623
Chromosome Location: 2q33-q35
Pathway: Class B/2 (Secretin family receptors), organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Hedgehog Signaling Pathway, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem; Signal Transduction, organism-specific biosystem;
Function: cholesterol binding; patched binding; peptidase activity;

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