"VEGFA" Related Products

Recombinant Human VEGFA

Cat.No.: VEGFA-504H
Product Overview: rHu Vascular Endothelial Growth Factor expressed in CHO cells is a double, glycosylated, polypeptide chain containing full lenght VEGF containing 165 amino acids (VEGF-165).
Description: Recombinant Human Vascular Endothelial Growth Factor-A is expressed at high levels in certain tumor-derived cells but is produced by a wide variety of cell types. In contrast to other factors mitogenic for endothelial cells such as FGF-1, FGF-2 and PDGF, VEGF is synthesized as a precursor containing a typical hydrophobic secretory signal sequence of 26 amino acids. Glycosylation is not required for efficient secretion of VEGF. rHu VEGF-121 produced in E. coli is a double, non-glycosylated, polypeptide chain that contains 121 amino acids and has a molecular mass of 28.42 kDa.
Source: CHO Cells (Chinese Hamster Ovary Cells)
Species: Human
Form: The protein was lyophilized from a concentrated (1mg/mL) solution with no additives.
Bio-activity: Determined by its ability to stimulate 3H-Thymidine incorporation in human umbilical vein endothelial cells. The ED50 for this effect was found to be 2-6 ng/ml.
Molecular Mass: 42,000 Da (by non-reducing SDS-PAGE migration)
Purity: Purified by proprietary chromatographic techniques. SDS PAGE: Not more than 3% total contaminants. RP-HPLC: principal peak>97%.
Stability: Lyophilized Vascular Endothelial Growth Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18oC. Upon reconstitution, rh VEGF should be stored at 4oC between 2-7 days. For long term storage, it is recommended to add
Reconstitution: It is recommended to reconstitute the lyophilized Vascular Endothelial Growth Factor Human in sterile nanopure water to not less than 100μg/ml. It can then be further diluted in other aqueous solutions.
Warning: Please avoid freeze-thaw cycles
Gene Name: VEGFA vascular endothelial growth factor A [ Homo sapiens ]
Official Symbol: VEGFA
Synonyms: VEGFA; vascular endothelial growth factor A; vascular endothelial growth factor , VEGF; VEGF A; VPF; vascular permeability factor; VEGF; MVCD1; MGC70609;
mRNA Refseq: NM_001025366
Protein Refseq: NP_001020537
UniProt ID: P15692
Chromosome Location: 6p12
Pathway: Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specifi
Function: cell surface binding; chemoattractant activity; cytokine activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; growth factor activity; heparin binding; heparin binding; platelet-derived growth factor recep

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