"FGF19" Related Products


Recombinant Human FGF19, Fc-tagged

Cat.No.: FGF19-252H
Product Overview: Signal peptide and human FGF-19 (aa 1-216) are fused at the C-terminus the Fc portion of human IgG1.
Description: FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
Source: HEK293 Cells
Species: Human
Tag: Fc
Form: Lyophilized from 0.2μm-filtered solution in PBS, pH 7.2.
Molecular Mass: ~50kDa (SDS-PAGE)
Purity: ≥90% (SDS-PAGE)
Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name: FGF19 fibroblast growth factor 19 [ Homo sapiens ]
Official Symbol: FGF19
Synonyms: FGF19; fibroblast growth factor 19; FGF-19;
Gene ID: 9965
mRNA Refseq: NM_005117
Protein Refseq: NP_005108
MIM: 603891
UniProt ID: O95750
Chromosome Location: 11q13.1
Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR4 ligand binding and activation, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem;
Function: fibroblast growth factor receptor binding; growth factor activity; protein binding; protein tyrosine kinase activity;

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