Recombinant Human FGF19, Fc-tagged

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Recombinant Human FGF19, Fc-tagged

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Cat.No. : FGF19-252H
Product Overview : Signal peptide and human FGF-19 (aa 1-216) are fused at the C-terminus the Fc portion of human IgG1.
Description : FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
Source : HEK293 Cells
Species : Human
Tag : Fc
Form : Lyophilized from 0.2μm-filtered solution in PBS, pH 7.2.
Molecular Mass : ~50kDa (SDS-PAGE)
Purity : ≥90% (SDS-PAGE)
Stability : Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : FGF19 fibroblast growth factor 19 [ Homo sapiens ]
Official Symbol : FGF19
Synonyms : FGF19; fibroblast growth factor 19; FGF-19;
Gene ID : 9965
mRNA Refseq : NM_005117
Protein Refseq : NP_005108
MIM : 603891
UniProt ID : O95750
Chromosome Location : 11q13.1
Pathway : Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR4 ligand binding and activation, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem;
Function : fibroblast growth factor receptor binding; growth factor activity; protein binding; protein tyrosine kinase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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