"FGF19" Related Products

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Recombinant Human FGF19, Fc-tagged

Cat.No. : FGF19-252H
Product Overview : Signal peptide and human FGF-19 (aa 1-216) are fused at the C-terminus the Fc portion of human IgG1.
Description : FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
Source : HEK293 Cells
Species : Human
Tag : Fc
Form : Lyophilized from 0.2μm-filtered solution in PBS, pH 7.2.
Molecular Mass : ~50kDa (SDS-PAGE)
Purity : ≥90% (SDS-PAGE)
Stability : Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : FGF19 fibroblast growth factor 19 [ Homo sapiens ]
Official Symbol : FGF19
Synonyms : FGF19; fibroblast growth factor 19; FGF-19;
Gene ID : 9965
mRNA Refseq : NM_005117
Protein Refseq : NP_005108
MIM : 603891
UniProt ID : O95750
Chromosome Location : 11q13.1
Pathway : Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR4 ligand binding and activation, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem;
Function : fibroblast growth factor receptor binding; growth factor activity; protein binding; protein tyrosine kinase activity;

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