Native Human Factor H

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Native Human Factor H

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Cat.No. : CFH-115H
Product Overview : Complement factor H (fH) is purified from normal human serum.
Description : It is an essential regulatory component of the alternative pathway of complement. It is critical for prevention of complement activation on host cells and tissues, especially the kidney. It has two functional activities: 1) it controls the formation and decay of the alternative pathway C3/C5 convertase (decay accelerating activity) and 2) it acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H (cofactor activity).
Source : Human serum
Species : Human
Form : Frozen liquid. 10 mM sodium phosphate, 145 mM NaCl, pH 7.3.
Bio-activity : >90% versus normal human serum standard
Molecular Mass : 155,000 Da (single chain)
Purity : ≥95% by SDS-PAGE
Storage : Store at -70°C or below. Avoid freeze/thaw.
Concentration : 1 mg/ml
Gene Name : CFH complement factor H [ Homo sapiens ]
Official Symbol : CFH
Synonyms : CFH; complement factor H; H factor 1 (complement) , HF, HF1, HF2; age related maculopathy susceptibility 1; ARMS1; beta 1H; FHL1; H factor 2 (complement); HUS; beta-1H; factor H; factor H-like 1; beta-1-H-globulin; H factor 1 (complement); adrenomedullin
Gene ID : 3075
mRNA Refseq : NM_000186
Protein Refseq : NP_000177
MIM : 134370
UniProt ID : P08603
Chromosome Location : 1q32
Pathway : Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Regulation of Complement cascade, organism-specific biosystem; Staphylococcus aureus infection, organism-specific biosystem;

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