Active Native Human Factor H

• Cat.No.: CFH-115H
• Product Overview: Complement factor H (fH) is purified from normal human serum.

Specification

• Description: It is an essential regulatory component of the alternative pathway of complement. It is critical for prevention of complement activation on host cells and tissues, especially the kidney. It has two functional activities: 1) it controls the formation and decay of the alternative pathway C3/C5 convertase (decay accelerating activity) and 2) it acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H (cofactor activity).
• Source: Human serum
• Species: Human
• Form: Frozen liquid. 10 mM sodium phosphate, 145 mM NaCl, pH 7.3.
• Bio-activity: >90% versus normal human serum standard
• Molecular Mass: 155,000 Da (single chain)
• Purity: ≥95% by SDS-PAGE
• Storage: Store at -70°C or below. Avoid freeze/thaw.
• Concentration: 1 mg/ml

Gene Information

• Gene Name: CFH complement factor H [ Homo sapiens ]
• Official Symbol: CFH
• Synonyms: CFH; complement factor H; H factor 1 (complement) , HF, HF1, HF2; age related maculopathy susceptibility 1; ARMS1; beta 1H; FHL1; H factor 2 (complement); HUS; beta-1H; factor H; factor H-like 1; beta-1-H-globulin; H factor 1 (complement); adrenomedullin
• Gene ID: 3075
• mRNA Refseq: NM_000186
• Protein Refseq: NP_000177
• MIM: 134370
• UniProt ID: P08603
• Chromosome Location: 1q32
• Pathway: Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Regulation of Complement cascade, organism-specific biosystem; Staphylococcus aureus infection, organism-specific biosystem