Recombinant Human TRIB3, GST-tagged
Cat.No. : | TRIB3-25H |
Product Overview : | Recombinant full-length human TRIB3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | TRIB3 or tribbles homolog 3 protein encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB3 is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. TRIB3 can negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 modulation by H. pylori and/or its products may be an important mechanism of H. pylori-associated pathogenesis. TRIB3 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. TRIB3 is highly expressed in pancreas, peripheral blood leukocytes, and bone marrow. |
Source : | Sf9 insect cells using baculovirus |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~69 kDa |
Applications : | Western Blot |
Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | TRIB3 tribbles homolog 3 (Drosophila) [ Homo sapiens ] |
Official Symbol : | TRIB3 |
Synonyms : | TRIB3; tribbles homolog 3 (Drosophila); C20orf97, chromosome 20 open reading frame 97; tribbles homolog 3; dJ1103G7.3; TRB3; TRB-3; p65-interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; neuronal cell death inducible putative kinase; neuronal cell death-inducible putative kinase; NIPK; SINK; SKIP3; C20orf97; |
Gene ID : | 57761 |
mRNA Refseq : | NM_021158 |
Protein Refseq : | NP_066981 |
MIM : | 607898 |
UniProt ID : | Q96RU7 |
Chromosome Location : | 20p13-p12.2 |
Pathway : | Activation of PKB, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem; Disease, organism-specific biosystem; |
Function : | ATP binding; enzyme binding; NOT kinase activity; protein binding; protein kinase binding; protein kinase binding; protein kinase inhibitor activity; transcription corepressor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity; |
Products Types
◆ Recombinant Protein | ||
TRIB3-0563H | Recombinant Human TRIB3 Protein (R2-G358), His/GST tagged | +Inquiry |
TRIB3-0564H | Recombinant Human TRIB3 Protein (R2-G358), Tag Free | +Inquiry |
TRIB3-3073H | Recombinant Human TRIB3 protein(Met1-Gly358), GST-tagged | +Inquiry |
TRIB3-5925R | Recombinant Rat TRIB3 Protein, His (Fc)-Avi-tagged | +Inquiry |
TRIB3-12130Z | Recombinant Zebrafish TRIB3 | +Inquiry |
◆ Lysates | ||
TRIB3-657HCL | Recombinant Human TRIB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionTRIB3 has been implicated in promoting cancer cell proliferation, survival, and metastasis in various types of cancer.
Targeting TRIB3 may have implications for the treatment of cardiovascular diseases, including atherosclerosis.
TRIB3 has been shown to regulate insulin signaling and glucose metabolism, and its overexpression has been linked to insulin resistance and type 2 diabetes.
Yes, targeting TRIB3 may be a potential strategy for inhibiting cancer cell growth and metastasis.
TRIB3 has been implicated in several diseases, including diabetes, cancer, and cardiovascular diseases.
Customer Reviews (3)
Write a reviewThe manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.
Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the TRIB3 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.
They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the TRIB3 protein.
Ask a Question for All TRIB3 Products
Required fields are marked with *
My Review for All TRIB3 Products
Required fields are marked with *
Inquiry Basket