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Recombinant Human TRIB3, GST-tagged

Cat.No. : TRIB3-25H
Product Overview : Recombinant full-length human TRIB3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Description : TRIB3 or tribbles homolog 3 protein encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB3 is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. TRIB3 can negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 modulation by H. pylori and/or its products may be an important mechanism of H. pylori-associated pathogenesis. TRIB3 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. TRIB3 is highly expressed in pancreas, peripheral blood leukocytes, and bone marrow.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~69 kDa
Applications : Western Blot
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : TRIB3 tribbles homolog 3 (Drosophila) [ Homo sapiens ]
Official Symbol : TRIB3
Synonyms : TRIB3; tribbles homolog 3 (Drosophila); C20orf97, chromosome 20 open reading frame 97; tribbles homolog 3; dJ1103G7.3; TRB3; TRB-3; p65-interacting inhibitor of NF-kappaB; p65-interacting inhibitor of NF-kappa-B; neuronal cell death inducible putative kinase; neuronal cell death-inducible putative kinase; NIPK; SINK; SKIP3; C20orf97;
Gene ID : 57761
mRNA Refseq : NM_021158
Protein Refseq : NP_066981
MIM : 607898
UniProt ID : Q96RU7
Chromosome Location : 20p13-p12.2
Pathway : Activation of PKB, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipogenesis, organism-specific biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem; Disease, organism-specific biosystem;
Function : ATP binding; enzyme binding; NOT kinase activity; protein binding; protein kinase binding; protein kinase binding; protein kinase inhibitor activity; transcription corepressor activity; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does TRIB3 contribute to cancer progression? 05/29/2021

TRIB3 has been implicated in promoting cancer cell proliferation, survival, and metastasis in various types of cancer.

Can TRIB3 be a potential therapeutic target for cardiovascular diseases? 01/15/2020

Targeting TRIB3 may have implications for the treatment of cardiovascular diseases, including atherosclerosis.

How does TRIB3 affect diabetes? 04/24/2018

TRIB3 has been shown to regulate insulin signaling and glucose metabolism, and its overexpression has been linked to insulin resistance and type 2 diabetes.

Can targeting TRIB3 be a potential strategy for cancer therapy? 02/18/2018

Yes, targeting TRIB3 may be a potential strategy for inhibiting cancer cell growth and metastasis.

What are the clinical implications of TRIB3 protein? 04/23/2017

TRIB3 has been implicated in several diseases, including diabetes, cancer, and cardiovascular diseases.

Customer Reviews (3)

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Reviews
02/16/2021

    The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.

    07/29/2019

      Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the TRIB3 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.

      08/05/2016

        They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the TRIB3 protein.

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