Recombinant Rat Arpc2, His-tagged
Cat.No. : | Arpc2-3105R |
Product Overview : | Actin-related protein 2/3 complex subunit 2 (Arpc2) |
- Specification
- Gene Information
- Related Products
Source : | E. Coli or Yeast |
Species : | Rat |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 300 |
Purity : | >90% |
Notes : | Small volumes of Arpc2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | Arpc2 actin related protein 2/3 complex, subunit 2 [ Rattus norvegicus ] |
Official Symbol : | Arpc2 |
Synonyms : | ARPC2; actin related protein 2/3 complex, subunit 2; actin-related protein 2/3 complex subunit 2; p34-ARC; arp2/3 complex 34 kDa subunit; |
Gene ID : | 301511 |
mRNA Refseq : | NM_001106919 |
Protein Refseq : | NP_001100389 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem |
Function : | actin binding; |
Products Types
◆ Recombinant Protein | ||
Arpc2-1725M | Recombinant Mouse Arpc2 Protein, Myc/DDK-tagged | +Inquiry |
ARPC2-245R | Recombinant Rhesus Macaque ARPC2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ARPC2-151H | Recombinant Human ARPC2 Protein, His-tagged | +Inquiry |
ARPC2-7566H | Recombinant Human ARPC2, His-tagged | +Inquiry |
ARPC2-5196H | Recombinant Human ARPC2 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ARPC2-8685HCL | Recombinant Human ARPC2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
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Q&As (6)
Ask a questionThe Arp2/3 complex, including ARPC2, is essential for various cellular processes. It plays a critical role in cell migration and adhesion, enabling cells to move and change shape. The complex is also involved in endocytosis, phagocytosis, and vesicle trafficking, regulating membrane dynamics. Additionally, ARPC2 and the Arp2/3 complex contribute to cell division, neuronal development, and immune cell function.
The expression of ARPC2 can be regulated transcriptionally through the binding of specific transcription factors to the promoter region of the ARPC2 gene. Additionally, post-transcriptional mechanisms like microRNAs or RNA-binding proteins can also affect the stability or translation efficiency of ARPC2 mRNA. Furthermore, epigenetic modifications, such as DNA methylation or histone acetylation, can play a role in regulating ARPC2 gene expression.
Mutations in the ARPC2 gene have been linked to a rare genetic disorder called Wiskott-Aldrich syndrome (WAS). WAS is characterized by immune system abnormalities, eczema, and a higher risk of developing certain types of cancer. Although mutations in the ARPC2 gene are relatively rare in WAS, they can disrupt the normal function of the Arp2/3 complex, leading to actin cytoskeleton defects.
Yes, the expression of the ARPC2 gene can be regulated during development. Transcription factors specific to certain developmental stages or tissues can bind to the regulatory regions of the gene and control its expression. Additionally, epigenetic modifications may also influence the expression patterns of ARPC2 during development.
Currently, there are no specific inhibitors or activators targeting ARPC2 directly. However, various compounds and drugs that target the Arp2/3 complex or actin cytoskeleton dynamics in general can indirectly impact the function of ARPC2. These include small molecule inhibitors of actin polymerization and drugs that modulate actin-binding proteins involved in regulating ARPC2 activity.
ARPC2 interacts with several other proteins and complexes involved in actin cytoskeleton regulation. It forms a stable complex with other subunits (ARPC1-5) to constitute the Arp2/3 complex. This complex interacts with nucleation promoting factors (NPFs) such as WASP and WAVE, which facilitate actin filament branching. Furthermore, ARPC2 can also interact with actin-binding proteins and signaling molecules, leading to cytoskeletal rearrangements and cellular responses.
Customer Reviews (3)
Write a reviewIts remarkable sensitivity and specificity make it a valuable tool for accurate and robust data analysis, bolstering the credibility of research outcomes.
Notably, it exhibits exceptional performance in ELISA assays, providing reliable and precise results in the detection and quantification of target molecules.
Highly recommended!
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