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Recombinant Mouse Akirin2, His-tagged

Cat.No. : Akirin2-3245M
Product Overview : Akirin-2 (Akirin2)
  • Specification
  • Gene Information
  • Related Products
Source : E. Coli or Yeast
Species : Mouse
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 201
Purity : >90%
Notes : Small volumes of Akirin2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : Akirin2 akirin 2 [ Mus musculus ]
Official Symbol : Akirin2
Synonyms : AKIRIN2; akirin 2; akirin-2; AA114675; AA522011; AU019887; Akirin-2; 2700059D21Rik; MGC90611; RP23-176N13.3;
Gene ID : 433693
mRNA Refseq : NM_001007589
Protein Refseq : NP_001007590

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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How is AKIRIN2 regulated? 09/27/2022

AKIRIN2 regulation can occur through various mechanisms, including post-translational modifications (such as phosphorylation), protein-protein interactions, and changes in gene expression levels.

What research is currently being conducted on AKIRIN2? 06/04/2022

Current research on AKIRIN2 is focused on understanding its precise molecular mechanisms, its role in immune cell development and function, and its involvement in different diseases. Additionally, studies are exploring potential therapeutic targets related to AKIRIN2.

Are there any known interacting proteins or partners of AKIRIN2? 09/02/2021

Yes, AKIRIN2 interacts with various proteins involved in gene regulation, including components of the SWI/SNF chromatin remodeling complex and the NF-κB signaling pathway. These interactions are important for its function in regulating gene expression.

In which tissues or cell types is AKIRIN2 expressed? 03/08/2021

AKIRIN2 is expressed in various tissues and cell types, with higher expression levels observed in immune cells, such as macrophages and lymphocytes. It is also expressed in other tissues, including skeletal muscle and the nervous system.

How is AKIRIN2 involved in the development of the immune system? 08/01/2020

AKIRIN2 is critical for immune cell development and function. It helps regulate the expression of genes necessary for immune cell differentiation, maturation, and activation. AKIRIN2-deficient mice have shown abnormalities in immune cell populations and impaired immune responses.

Are there any known AKIRIN2 inhibitors or activators? 06/01/2020

Currently, there are no specific inhibitors or activators of AKIRIN2 reported in the literature. However, identifying small molecules or compounds that can modulate AKIRIN2's activity may be a future direction for therapeutic interventions.

How does AKIRIN2 interact with other proteins or signaling pathways? 09/08/2019

AKIRIN2 interacts with various proteins and signaling pathways to carry out its functions. It can physically interact with transcription factors, such as NF-κB and AP-1, to modulate their activity and influence gene expression. AKIRIN2 has also been shown to interact with other proteins involved in immune responses, such as IKKβ and IκBα, which are part of the NF-κB signaling pathway. Additionally, AKIRIN2 can form complexes with other co-regulators, such as p300/CBP and BRG1, which are involved in chromatin remodeling and transcriptional regulation.

What are the similarities and differences between AKIRIN1 and AKIRIN2? 09/03/2019

AKIRIN1 and AKIRIN2 are members of the same protein family and share similar structural features. Both proteins are involved in gene regulation and have overlapping functions in immune responses. However, they also exhibit some degree of functional specificity and can regulate different sets of genes in certain contexts.

What happens when AKIRIN2 is disrupted or mutated? 06/17/2019

Disruption or mutation of AKIRIN2 can lead to dysregulation of immune-related genes and processes. This can result in impaired immune responses, increased susceptibility to infections, and the development of inflammatory disorders or autoimmune diseases.

How is AKIRIN2's role in cancer being investigated? 02/14/2019

Several studies have identified AKIRIN2 as a potential player in cancer development and progression. It may contribute to tumor growth by promoting inflammation, modulating the immune response, or affecting gene expression patterns. Further research is required to fully comprehend its specific involvement in different types of cancer.

Can AKIRIN2 be a potential therapeutic target? 11/27/2018

The potential of AKIRIN2 as a therapeutic target is being explored. By understanding its role in immune regulation and its interactions with other proteins, researchers aim to develop targeted therapies that can modulate immune responses in conditions such as autoimmune diseases or cancer.

Are there any diseases or conditions associated with AKIRIN2 mutations? 03/23/2018

Currently, there are no known human diseases directly linked to AKIRIN2 mutations. However, dysregulation of AKIRIN2 expression or function has been implicated in various pathological conditions, including autoimmune diseases, cancer, and cardiovascular disorders. Further research is needed to establish a direct causal relationship between AKIRIN2 mutations and these diseases

Is there any therapeutic potential for targeting AKIRIN2? 01/23/2017

The therapeutic potential of targeting AKIRIN2 remains an area of active research. Given its involvement in immune responses and its interactions with signaling pathways, AKIRIN2 could be a potential target for modulating immune-related diseases, such as autoimmune disorders and inflammation-driven conditions. Additionally, as AKIRIN2 has been implicated in cancer and cardiac remodeling, it could be explored as a therapeutic target in these contexts. However, the development of specific AKIRIN2-targeted therapies requires a deeper understanding of its mechanisms and functions in different diseases.

Is AKIRIN2 involved in any cellular processes or signaling pathways other than immune response? 08/19/2016

Yes, AKIRIN2 is involved in a range of cellular processes and signaling pathways beyond immune response. It has been implicated in muscle development and regeneration, where it interacts with muscle-specific transcription factors to regulate muscle gene expression. AKIRIN2 is also involved in embryonic development, hematopoiesis, and cardiac remodeling. Additionally, AKIRIN2 has been shown to interact with the Wnt signaling pathway and Hippo signaling pathway, suggesting its potential involvement in various developmental and cellular processes.

Are there any diseases or conditions associated with AKIRIN2? 06/17/2016

Recent studies have implicated AKIRIN2 in certain diseases and conditions, including inflammation-related disorders, autoimmune diseases, and cancer. However, more research is needed to fully understand its role in these conditions.

What are the future research directions for AKIRIN2? 04/21/2015

Future research on AKIRIN2 will likely focus on unraveling its precise mechanisms of action, exploring its involvement in different diseases, and identifying potential therapeutic strategies targeting AKIRIN2 or its associated signaling pathways. Additionally, understanding the interplay between AKIRIN2 and other proteins in gene regulation will be vital for advancing our knowledge in this field.

Are there any other known functions of AKIRIN2 outside of the immune system? 02/12/2015

While AKIRIN2's role in the immune system is well-studied, there is emerging evidence suggesting its involvement in other biological processes. For example, AKIRIN2 has been implicated in skeletal muscle development, where it plays a role in myogenesis by regulating muscle-specific gene expression. Additionally, AKIRIN2 has been linked to embryonic development, hematopoiesis, and cardiac remodeling. Further investigations are necessary to fully understand the extent of AKIRIN2's functions in these processes.

Can AKIRIN2 be used as a biomarker for any diseases? 02/01/2015

The potential of AKIRIN2 as a biomarker for specific diseases is still under investigation. Some studies have suggested that AKIRIN2 expression levels may have diagnostic or prognostic value in certain cancers, such as hepatocellular carcinoma or breast cancer. However, further studies with larger cohorts are necessary to validate its utility as a biomarker and determine its specificity and sensitivity.

Customer Reviews (4)

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Reviews
04/22/2017

    This exceptional technical support ensures that I have access to the necessary guidance and expertise to overcome any obstacles that may arise during my research journey.

    10/31/2016

      Its reliability and the assurance of effective problem-solving provide me with the confidence to proceed with my research and achieve the best possible outcomes.

      10/22/2016

        Their dedicated team of experts stands ready to assist in resolving any challenges or concerns I may encounter.

        12/01/2015

          To sum up, the AKIRIN2 protein's remarkable quality, tailored to meet my experimental needs, positions it as the perfect choice.

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