Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Swine IL-12 p40

Cat.No. : IL12B-84S
Product Overview : Swine IL-12/IL-23 p40 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
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Description : IL-12 is a member of the IL-12 family, which includes IL-12, IL-23, IL-27, and IL-35. Like other IL-12 family members, IL-12 is a heterodimeric cytokine. IL-12 is encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer, and a homodimer of p40 are formed following protein synthesis. IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-gamma and TNF-alpha from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-gamma.
Source : Yeast
Species : Swine
Form : Lyophilized
Molecular Mass : 34.3 kDa
AA Sequence : IWELEKNVYV VELDWYPNAP GEMVVLTCNT PEEDGITWTS DQSSEVLGTG KTLTIHVKEF GDAGQYTCRK GGAVLSQSLL LLHKKEDGIW STDILKDQKE PKNKSFLKCE AKNYSGRFTC WWLTAISTDL KFSVKSSRGS TDPRGVTCGT ATLSEDLGEY KKYRVECQEG SACPAAEESL PIEVVLEAVH KLKYENYTSS FFIRDIIKPD PPKNLQLNPL KNSRHVEISW EYPDTWSTPH SYFSLMFGVQ VQGKNKREKK DKLFTDQISA KVTCHKDANI RVQARDRYYS SSWSEWASVS CN (302)
Applications : The Swine IL-12/IL-23 p40 protein can be used in cell culture, as an IL-12/IL-23 p40 ELISA Standard, and as a Western Blot Control.
Storage : -20 C

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Could you explain the use of ChIP-seq in studying IL12B transcriptional regulation? 05/12/2021

ChIP-seq identifies regulatory elements controlling IL12B gene expression.

Can you elaborate on the use of reporter assays to monitor IL12B promoter activity? 05/02/2021

Reporter assays monitor IL12B promoter activity under varying conditions.

What methods evaluate IL12B's response to different pathogenic stimuli in primary cells? 10/30/2020

Primary cell stimulation assays gauge IL12B response to pathogens.

How does siRNA knockdown of IL12B elucidate its role in immune cell activation? 05/25/2020

siRNA knockdown uncovers IL12B's role in immune cell activation pathways.

How does recombinant protein expression and purification aid in IL12B functional studies? 04/30/2020

Recombinant protein expression enables functional IL12B studies in vitro.

How does co-immunoprecipitation validate IL12B's association with signaling partners? 04/12/2018

Co-IP validates IL12B's binding to specific signaling partners.

What techniques are employed to analyze the impact of IL12B genetic variants on protein function? 12/03/2017

Genetic variant analysis reveals impacts on IL12B protein function.

How does flow cytometry reveal IL12B's expression dynamics in different immune cell subsets? 10/31/2017

Flow cytometry profiles IL12B expression across diverse immune cell types.

What experimental approaches determine IL12B's cytokine secretion kinetics upon stimulation? 09/29/2017

Cytokine secretion assays measure IL12B's response kinetics to stimuli.

What are the methods to assess IL12B's protein-protein interactions in a cellular context? 08/22/2017

Co-IP and immunoprecipitation assess IL12B's interactions with other proteins.

Customer Reviews (3)

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Reviews
04/08/2020

    Good for cytokine assays.

    01/06/2020

      Effective in Th2 cell differentiation.

      01/12/2019

        High yield in expression.

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