Recombinant Human Il21, HIgG1 Fc-tagged, mutant Il21-001H

Recombinant Human Il21, HIgG1 Fc-tagged, mutant

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Cat.No. : Il21-001H Optional Service: Optional requirements on this protein
Product Overview : The extracellular domain of human IL-21 (NP_068575.1) (Gln32-Ser162)(Gln145Asp,Gln150Asp) is fused to the N-terminus of the Fc region of mutant human IgG1.
Description : This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. Theencoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation,proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells andcytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus,psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoformshave been observed for this gene.
Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged, mutant
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured in a cell proliferation assay using N1186 human T cells.
Molecular Mass : 41KDa (monomer)
AA Sequence : (Gln32-Ser 162)(Gln14 5Asp,Gln15 0Asp)
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : IL21 interleukin 21 [ Homo sapiens ]
Official Symbol : IL21
Synonyms : IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21;
Gene ID : 59067
mRNA Refseq : NM_001207006
Protein Refseq : NP_001193935
MIM : 605384
UniProt ID : Q9HBE4
Chromosome Location : 4q26-q27
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine activity; cytokine receptor binding; interleukin-2 receptor binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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