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Recombinant Human Chemokine (C-X-C motif) Ligand 13, HIgG1 Fc-tagged

Cat.No.: CXCL13-123H
Product Overview: The extracellular domain of human CXCL13 (AAH12589.1)(Val23-Arg94) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Description: B lymphocyte chemoattractant, independently cloned and named Angie, is a CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer"s patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt"s lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
Source: CHO cell
Species: Human
Tag: HIgG1 Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to chemoattract BaF3 mouse proB cells.
Molecular Mass: 35KDa (monomer)
AA Sequence: (Val23-Arg94
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: CXCL13 chemokine (C-X-C motif) ligand 13 [ Homo sapiens ]
Official Symbol: CXCL13
Synonyms: CXCL13; chemokine (C-X-C motif) ligand 13; SCYB13, small inducible cytokine B subfamily (Cys X Cys motif), member 13 (B cell chemoattractant); C-X-C motif chemokine 13; ANGIE; ANGIE2; B cell chemoattractant; BCA 1; BLC; BLR1L; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); BCA1; BCA-1; SCYB13;
Gene ID: 10563
mRNA Refseq: NM_006419
Protein Refseq: NP_006410
MIM: 605149
UniProt ID: O43927
Chromosome Location: 4q21
Pathway: CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function: CCR10 chemokine receptor binding; CXCR3 chemokine receptor binding; CXCR5 chemokine receptor binding; chemokine activity; fibroblast growth factor binding; heparin binding; protein heterodimerization activity; receptor agonist activity;

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