Recombinant Human Chemokine (C-X-C motif) Ligand 13, HIgG1 Fc-tagged

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Recombinant Human Chemokine (C-X-C motif) Ligand 13, HIgG1 Fc-tagged

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Cat.No. : CXCL13-123H
Product Overview : The extracellular domain of human CXCL13 (AAH12589.1)(Val23-Arg94) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Description : B lymphocyte chemoattractant, independently cloned and named Angie, is a CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer"s patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt"s lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles.
Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to chemoattract BaF3 mouse proB cells.
Molecular Mass : 35KDa (monomer)
AA Sequence : (Val23-Arg 94
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : CXCL13 chemokine (C-X-C motif) ligand 13 [ Homo sapiens ]
Official Symbol : CXCL13
Synonyms : CXCL13; chemokine (C-X-C motif) ligand 13; SCYB13, small inducible cytokine B subfamily (Cys X Cys motif), member 13 (B cell chemoattractant); C-X-C motif chemokine 13; ANGIE; ANGIE2; B cell chemoattractant; BCA 1; BLC; BLR1L; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); BCA1; BCA-1; SCYB13;
Gene ID : 10563
mRNA Refseq : NM_006419
Protein Refseq : NP_006410
MIM : 605149
UniProt ID : O43927
Chromosome Location : 4q21
Pathway : CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : CCR10 chemokine receptor binding; CXCR3 chemokine receptor binding; CXCR5 chemokine receptor binding; chemokine activity; fibroblast growth factor binding; heparin binding; protein heterodimerization activity; receptor agonist activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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