"IL1R2" Related Products

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Recombinant Human IL1R2, MIgG2a Fc-tagged

Cat.No.: IL1R2-120H
Product Overview: The extracellular domain of human IL-1R2 (AAH39031.1)(Phe14-Glu343) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.
Description: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage.
Source: CHO cell
Species: Human
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to inhibit IL-1 beta-dependent proliferation.
Molecular Mass: 64KDa (monomer)
AA Sequence: Phe14-Glu343
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: IL1R2 interleukin 1 receptor, type II [ Homo sapiens ]
Official Symbol: IL1R2
Synonyms: IL1R2; interleukin 1 receptor, type II; IL1RB; interleukin-1 receptor type 2; CD121b; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2; IL-1R-beta; antigen CDw121b; IL-1 type II receptor; interleukin-1 receptor beta; interleukin-1 receptor type II; CD121 antigen-like family member B; type II interleukin-1 receptor, beta; MGC47725;
Gene ID: 7850
mRNA Refseq: NM_004633
Protein Refseq: NP_004624
MIM: 147811
UniProt ID: P27930
Chromosome Location: 2q12
Pathway: Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Function: interleukin-1 receptor activity; interleukin-1, Type II, blocking receptor activity; protein binding; receptor activity;

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