Active Recombinant Human BMP7, HIgG1 Fc-tagged, mutant
Cat.No. : | BMP7-508H |
Product Overview : | The extracellular domain of human BMP-7 (NP_001710.1) (Arg292-Cys430) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell. |
- Specification
- Gene Information
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Description : | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. |
Source : | CHO cells |
Species : | Human |
Tag : | HIgG1 Fc-tagged, mutant |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its ability to induce alkaline phosphatase production. |
Molecular Mass : | 42KDa (monomer) |
AA Sequence : | Arg292-Cys430 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | BMP7 bone morphogenetic protein 7 [ Homo sapiens ] |
Official Symbol : | BMP7 |
Synonyms : | BMP7; bone morphogenetic protein 7; OP 1; osteogenic protein 1; BMP-7; OP-1; |
Gene ID : | 655 |
mRNA Refseq : | NM_001719 |
Protein Refseq : | NP_001710 |
MIM : | 112267 |
UniProt ID : | P18075 |
Chromosome Location : | 20q13 |
Pathway : | ALK2 signaling events, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem; |
Function : | cytokine activity; growth factor activity; protein binding; contributes_to protein binding; |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, potential side effects include inflammation, swelling, and in rare cases, excessive bone growth.
BMP7 stimulates the differentiation of mesenchymal stem cells into osteoblasts, promoting bone formation and repair.
Yes, BMP7 is often used in spinal fusion surgeries to stimulate bone growth and enhance the fusion process.
BMP7 is commonly used in conditions such as bone fractures, spinal fusions, and non-union fractures.
While orthopedics is a primary application, BMP7 is also being explored for its potential in treating kidney and eye disorders.
Customer Reviews (3)
Write a reviewBy incorporating the BMP7 protein into electron microscopy studies, researchers gain insights into the intricate three-dimensional architecture of proteins, facilitating a deeper comprehension of their functions and aiding in the development of novel therapeutics.
Its reliability and effectiveness in generating accurate data make it an indispensable resource, driving scientific exploration and advancing our understanding of protein structure and function
The BMP7 protein is an exceptional product that meets the highest standards of quality, making it an ideal choice to fulfill my experimental requirements.
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