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Active Recombinant Human BMP7, HIgG1 Fc-tagged, mutant

Cat.No. : BMP7-508H
Product Overview : The extracellular domain of human BMP-7 (NP_001710.1) (Arg292-Cys430) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.
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Description : The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity.
Source : CHO cells
Species : Human
Tag : HIgG1 Fc-tagged, mutant
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to induce alkaline phosphatase production.
Molecular Mass : 42KDa (monomer)
AA Sequence : Arg292-Cys430
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : BMP7 bone morphogenetic protein 7 [ Homo sapiens ]
Official Symbol : BMP7
Synonyms : BMP7; bone morphogenetic protein 7; OP 1; osteogenic protein 1; BMP-7; OP-1;
Gene ID : 655
mRNA Refseq : NM_001719
Protein Refseq : NP_001710
MIM : 112267
UniProt ID : P18075
Chromosome Location : 20q13
Pathway : ALK2 signaling events, organism-specific biosystem; BMP receptor signaling, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem;
Function : cytokine activity; growth factor activity; protein binding; contributes_to protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any potential side effects or risks associated with BMP7 treatment? 01/31/2023

Yes, potential side effects include inflammation, swelling, and in rare cases, excessive bone growth.

How does BMP7 contribute to bone healing? 03/08/2022

BMP7 stimulates the differentiation of mesenchymal stem cells into osteoblasts, promoting bone formation and repair.

Can BMP7 be used in spinal fusion surgeries? 05/13/2021

Yes, BMP7 is often used in spinal fusion surgeries to stimulate bone growth and enhance the fusion process.

In what medical conditions is BMP7 protein commonly used? 02/08/2018

BMP7 is commonly used in conditions such as bone fractures, spinal fusions, and non-union fractures.

Is BMP7 exclusively used in orthopedic applications? 01/13/2017

While orthopedics is a primary application, BMP7 is also being explored for its potential in treating kidney and eye disorders.

Customer Reviews (3)

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Reviews
01/08/2022

    By incorporating the BMP7 protein into electron microscopy studies, researchers gain insights into the intricate three-dimensional architecture of proteins, facilitating a deeper comprehension of their functions and aiding in the development of novel therapeutics.

    04/26/2021

      Its reliability and effectiveness in generating accurate data make it an indispensable resource, driving scientific exploration and advancing our understanding of protein structure and function

      05/13/2017

        The BMP7 protein is an exceptional product that meets the highest standards of quality, making it an ideal choice to fulfill my experimental requirements.

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