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Recombinant Mouse Icos, MIgG2a Fc-tagged

Cat.No.: Icos-1821M
Product Overview: The extracellular domain of mouse CD278 [ICOS] (NP_059508.2) (Glu21-Leu142) is fused to the N-terminus of the Fc region of mouse IgG2a.
Description: The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimersand plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Source: CHO cells
Species: Mouse
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its binding ability in a functional ELISA.
Molecular Mass: 40 KDa (monomer)
AA Sequence: Glu21-Leu142
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: Icos inducible T cell co-stimulator [ Mus musculus ]
Official Symbol: Icos
Synonyms: ICOS; inducible T cell co-stimulator; inducible T-cell costimulator; CD28-related protein 1; CD28 and CTLA-4-like protein; inducible T-cell co-stimulator; activation-inducible lymphocyte immunomediatory molecule; H4; CCLP; AILIM; CRP-1; Ly115;
Gene ID: 54167
mRNA Refseq: NM_017480
Protein Refseq: NP_059508
Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem;
Function: protein binding;

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