Recombinant Human LIPA, MYC/DDK-tagged

• Cat.No.: LIPA-11H
• Product Overview: Recombinant Human LIPA, fused with C-terminal MYC/DDK, was expressed in HEK293 cells.

Specification

• Description: This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene.
• Source: HEK293 cells
• Species: Human
• Tag: MYC/DDK
• Molecular Mass: 43 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: LIPA lipase A, lysosomal acid, cholesterol esterase [ Homo sapiens ]
• Official Symbol: LIPA
• Synonyms: LIPA; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase/cholesteryl ester hydrolase; CESD; LAL; Wolman disease; sterol esterase; cholesteryl esterase; lysosomal acid lipase; cholesterol ester hydrolase; acid cholesteryl ester hydrolase
• Gene ID: 3988
• mRNA Refseq: NM_000235
• Protein Refseq: NP_000226
• MIM: 613497
• UniProt ID: P38571
• Chromosome Location: 10q23.2-q23.3
• Pathway: Lysosome; Phase I, non P450; Steroid biosynthesis
• Function: lipase activity; sterol esterase activity