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Recombinant Cynomolgus TNFSF4, Fc-tagged

Cat.No.: TNFSF4-85C
Product Overview: A DNA sequence encoding the cynomolgus TNFSF4 (Gln51-Leu183) was expressed with the Fc region of mouse IgG1 at the N-terminus.
Description: OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
Source: Human Cells
Species: Cynomolgus
Tag: Fc
Predicted N Terminal: Asp
Form: Lyophilized from sterile PBS, pH 7.4.
Bio-activity: Immobilized Cynomolgus mFc-TNFSF4 at 10 μg/ml (100 μl/well) can bind human TNFRSF4-Fch, The EC50 of human TNFRSF4-Fch is 0.23-0.55 μg/ml.
Molecular Mass: The recombinant cynomolgus TNFSF4 is a disulfide-linked homodimer. The reduced monomer comprises 369 amino acids and has a calculated molecular mass of 42 KDa.The apparent molecular mass of it is approximately 48 KDa respectively in SDS-PAGE.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Purity: > 85 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name: TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol: TNFSF4
Synonyms: TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; hypothetical protein
Gene ID: 102141877
mRNA Refseq: XM_005540022
Protein Refseq: XP_005540079
Chromosome Location: 1
Pathway: Cytokine-cytokine receptor interaction

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