"CXCR4" Related Products


Recombinant Human CXCR4, Fc-tagged

Cat.No.: CXCR4-19H
Product Overview: Recombinant human CXCR4 Fc chimera (rhCXCR4-Fc), Met1-Ser46 was expressed in HEK293.
Description: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Source: HEK293
Species: Human
Tag: Fc
Form: Bulk protein in a 0.22 μm filtered solution of 50 mM tris, 100 mM glycine, pH7.5 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass: rhCXCR4-Fc is fused with Fc fragment of human IgG1 at N-terminal and has a predicted molecular mass of 32.8 kDa. In DTT-reduced SDS-PAGE, rhCXCR4-Fc protein migrates as 40-50 kDa poly peptide due to glycosylation.
Endotoxin: Less than 0.01ng endotoxin per μg rhCXCR4-Fc.
Purity: >95% purity as determined by SDS-PAGE of reduced rhCXCR4-Fc.
Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4oC-8oC); After reconstitution under sterile conditions for 1 month (4oC-8oC) or 3 months (-20oC to -70oC).
Gene Name: CXCR4 chemokine (C-X-C motif) receptor 4 [ Homo sapiens (human) ]
Official Symbol: CXCR4
Synonyms: CXCR4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; chemokine (C-X-C motif) receptor 4; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor
Gene ID: 7852
mRNA Refseq: NM_003467
Protein Refseq: NP_003458
MIM: 162643
UniProt ID: P61073
Chromosome Location: 2q21
Pathway: Binding and entry of HIV virion; Chemokine receptors bind chemokines; Class A/1 (Rhodopsin-like receptors)
Function: C-X-C chemokine receptor activity; G-protein coupled receptor activity; actin binding; coreceptor activity

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