"PTK2" Related Products

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Recombinant Human PTK2, GST-tagged

Cat. No. : PTK2-38H
Product Overview : Recombinant Human Active Focal Adhesion Kinase full length is a 146.7 kDa enzyme produced inSf9 cellswith an amino-terminal GST tag and purified via sequential chromatography. PTK2 is activated in-vitro by his tagged SRC.
Description : FAK is a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix.
Source : Baculovirus, Sf9 insect cells.
Amino Acid Sequence : MAPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRHNQTSL YKKAGTMAAA YLDPNLNHTP NSSTKTHLGT GMERSPGAME RVLKVFHYFE SNSEPTTWAS IIRHGDATDVRGIIQKIVDS HKVKHVACYG FRLSHLRSEE VHWLHVDMGV SSVREKYELA HPPEEWKYEL RIRYLPKGFL NQFTEDKPTL NFFYQQVKSD YMLEIADQVD QEIALKLGCL EIRRSYWEMR GNALEKKSNY EVLEKDVGLK RFFPKSLLDS VKAKTLRKLI QQTFRQFANL NREESILKFF EILSPVYRFD KECFKCALGS SWIISVELAI GPEEGISYLT DKGCNPTHLA DFTQVQTIQY SNSEDKDRKG MLQLKIAGAP EPLTVTAPSL TIAENMADLI DGYCRLVNGT SQSFIIRPQK EGERALPSIP KLANSEKQGM RTHAVSVSET DDYAEIIDEE DTYTMPSTRD YEIQRERIEL GRCIGEGQFG DVHQGIYMSP ENPALAVAIK TCKNCTSDSV REKFLQEALT MRQFDHPHIV KLIGVITENP VWIIMELCTL GELRSFLQVR KYSLDLASLI LYAYQLSTAL AYLESKRFVH RDIAARNVLV SSNDCVKLGD FGLSRYMEDS TYYKASKGKL PIKWMAPESI NFRRFTSASD VWMFGVCMWE ILMHGVKPFQ GVKNNDVIGR IENGERLPMP PNCPPTLYSL MTKCWAYDPS RRPRFTELKA QLSTILEEEK AQQEERMRME SRRQATVSWD SGGSDEAPPK PSRPGYPSPR SSEGFYPSPQ HMVQTNHYQV SGYPGSHGIT AMAGSIYPGQ ASLLDQTDSW NHRPQEIAMW QPNVEDSTVL DLRGIGQVLP THLMEERLIR QQQEMEEDQR WLEKEERFLK PDVRLSRGSI DREDGSLQGP IGNQHIYQPVGKPDPAAPPK KPPRPGAPGH LGSLASLSSP ADSYNEGVKL QPQEISPPPT ANLDRSNDKV YENVTGLVKA VIEMSSKIQP APPEEYVPMV KEVGLALRTLLATVDETIPL LPASTHREIE MAQKLLNSDL GELINKMKLA QQYVMTSLQQ EYKKQMLTAA HALAVDAKNL LDVIDQARLK MLGQTRPH.
Dilution Buffer : 20mM Tris pH-7.5, 10% Glycerol, 0.02% Triton X-100, 0.1mg/ml BSA, 0.5mM Na3VO4, 2mM DTT.
Purity : Greater than 70% as determined by SDS-PAGE.
Formulation : FADK is supplied in 50mM Tris pH-7.5, 150mM NaCl, 0.5mM EDTA, 0.02% Triton X-100, 2mM DTT, & 50% Glycerol.
Biological Activity : 72 nmole of phosphate transferred to poly [Glu,Tyr] 4:1 substrate/minute/mg of total protein at 30°C. Activity determined at a final protein concentration of 4μg/ml.
Storage : Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C to -80°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Gene Name : PTK2 PTK2 protein tyrosine kinase 2 [ Homo sapiens ]
Synonyms : PTK2; PTK-2 protein tyrosine kinase 2; FAK; FADK; FAK1; pp125FAK;Focal adhesion kinase 1; FADK 1; Protein-tyrosine kinase 2; Protein-tyrosine kinase 2; EC 2.7.10.2
Gene ID : 5747
mRNA Refseq : NM_005607
Protein Refseq : NP_005598
UniProt ID : Q05397
Chromosome Location : 8q24-qter
MIM : 600758
Pathway : Axon guidance; ErbB signaling pathway; Chemokine signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Pathways in cancer; Regulation of actin cytoskeleton; Small cell lung cancer; VEGF signaling pathway; Apoptosis; Axon guidance; Hemostasis; Integrin cell surface interactions
Function : ATP binding; SH2 domain binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; signal transducer activity; transferase activity

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