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Recombinant Mouse Tie1, Fc-tagged

Cat.No. : Tie1-88M
Product Overview : Recombinant Mouse Solubletyrosine kinase with immunoglobulin-like and EGF-like domains 1fused with the Fc part of human IgG1 produced inCHOis a monomeric, glycosylated, polypeptide containing 749 amino acids and having a total molecular mass of 260 kDa. Mouse TIE-1/Fc monomer has a calculated molecular mass of approximately 105 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 130 kDa protein in SDS-PAGE under reducing conditions. The TIE1 Fc Chimera is purified by proprietary chromatographic techniques.
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Cat. No. : Tie1-88M
Description : TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Whereas two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], so far no ligand was found for TIE-1.
Source : CHO Cells.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : TIE-1 Fc Chimera was lyophilized from a concentrated (1 mg/ml) sterile solution containing 1x PBS.
Solubility : It is recommended to reconstitute the lyophilized TIE-1 Fc Chimera in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage : Lyophilized sTIE-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TIE-1 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [ Mus musculus ]
Synonyms : Tie1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; TIE; tie-1; D430008P04Rik
Gene ID : 21846
mRNA Refseq : NM_011587
Protein Refseq : NP_035717
UniProt ID : Q06806
Chromosome Location : 4 50.0 cM
Function : ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can I increase the expression level of TIE1 protein? 02/25/2022

At present, there is no direct way to increase the expression level of TIE1 protein, but it can be improved by regulating gene expression and providing nutritional support.

What are the applications of TIE1 protein in drug discovery? 12/10/2020

This protein can be used as a target for the development of new drugs, or as a drug carrier for the targeted delivery of drugs.

What is the current state of development for TIE1? 12/04/2020

TIE1 is currently in clinical trials, including small molecule inhibitors against TIE1 and inhibitors against the TIE1 signaling pathway.

How can TIE1 be used as a biomarker in clinical practice? 06/07/2020

In clinical practice, the expression level of TIE1 can be detected to predict disease progression and prognosis, and to guide the choice of treatment regimen. For example, in the diagnosis and treatment of angiogenesis-related diseases, measuring the expression level of TIE1 can help doctors determine the type, stage, and prognosis of the disease, and guide the choice of treatment regimen.

What is the significance of studying the TIE1 protein? 05/06/2020

TIE1 protein can shed light on the mechanisms of angiogenesis and embryonic development, as well as the pathogenesis of certain angiogenesis-related diseases. In addition, it is of great significance for the development of new drugs and treatment strategies.

How about TIE1 protein related to autoimmune diseases? 02/21/2020

Studies have shown that TIE1 protein plays an important role in the pathogenesis of certain autoimmune diseases.

Customer Reviews (3)

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12/19/2022

    After repeated use, it can also maintain the stability of the performance, which makes me more confident in the experimental results.

    06/11/2022

      Green and pollution-free, it can be seen that the manufacturer is very environmentally conscious.

      01/29/2021

        The range of applications is breathtaking, and it can play an important role in any field.

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