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Recombinant Human C1S 293 Cell Lysate

Cat.No. : C1S-8131HCL
  • Specification
  • Gene Information
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Description : Antigen standard for complement component 1, s subcomponent (C1S), transcript variant 2 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : C1S complement component 1, s subcomponent [ Homo sapiens ]
Official Symbol : C1S
Synonyms : C1S; complement component 1, s subcomponent; complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s; FLJ44757;
Gene ID : 716
mRNA Refseq : NM_001734
Protein Refseq : NP_001725
MIM : 120580
UniProt ID : P09871
Chromosome Location : 12p13
Pathway : Classical antibody-mediated complement activation, organism-specific biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Creation of C4 and C2 activators, organism-specific biosystem;
Function : calcium ion binding; peptidase activity; serine-type endopeptidase activity;

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is C1S protein deficiency a rare condition? 10/07/2022

Yes, C1S protein deficiency is rare, but it is more common in patients with a family history of HAE.

What are the potential side effects or risks associated with C1S replacement therapy? 08/13/2022

Side effects can include infusion site reactions or hypersensitivity reactions, so treatment is typically administered under medical supervision.

How is C1S protein replacement therapy administered to patients with HAE? 10/02/2021

C1S protein replacement therapy is usually given intravenously, and the frequency of administration may vary depending on the patient's needs.

Can C1S protein be used in the treatment of conditions other than HAE? 01/09/2018

C1S replacement therapy is primarily used for HAE, but researchers are investigating its potential use in other complement-related disorders.

Are there any ongoing research efforts related to C1S protein in clinical applications? 11/20/2016

Yes, ongoing research aims to better understand the role of C1S in HAE and explore new treatment options, such as gene therapy.

Customer Reviews (3)

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Reviews
12/07/2018

    This level of sensitivity and specificity has streamlined my research and allowed for precise protein characterization.

    09/28/2018

      The protein bands detected were exceptionally distinct, enabling easy interpretation and accurate analysis of protein expression patterns.

      09/16/2018

        To summarize, the C1S protein is a highly recommended asset for various research endeavors, including ELISA, protein electron microscopy structure analysis, and Western blotting.

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