Recombinant Human BCL6 293 Cell Lysate
Cat.No. : | BCL6-8479HCL |
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- Gene Information
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Description : | Antigen standard for B-cell CLL/lymphoma 6 (BCL6), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Gene Name : | BCL6 B-cell CLL/lymphoma 6 [ Homo sapiens ] |
Official Symbol : | BCL6 |
Synonyms : | BCL6; B-cell CLL/lymphoma 6; zinc finger protein 51 , ZNF51; B-cell lymphoma 6 protein; BCL5; BCL6A; LAZ3; ZBTB27; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; ZNF51; |
Gene ID : | 604 |
mRNA Refseq : | NM_001706 |
Protein Refseq : | NP_001697 |
MIM : | 109565 |
UniProt ID : | P41182 |
Chromosome Location : | 3q27 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem; |
Function : | chromatin DNA binding; chromatin binding; metal ion binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; zinc ion binding; |
Products Types
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BCL6-306H | Recombinant Human BCL6 Protein, His-tagged | +Inquiry |
BCL6-441H | Recombinant Human BCL6 Protein, His (Fc)-Avi-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionChallenges include the need to develop specific and effective inhibitors of BCL6 function while minimizing off-target effects and ensuring tolerability in clinical settings.
Yes, genetic mutations and translocations involving the BCL6 gene have been linked to the development of certain lymphomas and other hematological malignancies.
BCL6 protein is crucial for the formation and maintenance of germinal centers, where it regulates the processes of somatic hypermutation and class-switch recombination in B cells.
Targeting BCL6 protein could potentially offer new therapeutic options by modulating immune responses and suppressing the aberrant production of autoantibodies in autoimmune diseases.
Yes, the assessment of BCL6 protein expression can provide valuable prognostic information, helping to predict patient outcomes and guide treatment strategies for lymphoma patients.
Customer Reviews (3)
Write a reviewIts stability and structural integrity make it an ideal candidate for studying protein structures at high resolution.
I am delighted to highly recommend the BCL6 Protein for researchers seeking excellent performance in Western blotting (WB) experiments and protein electron microscopy structure analysis
Its exceptional purity and integrity ensure clear and reliable bands, enabling accurate detection and quantification of target proteins.
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