Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human APBB1 293 Cell Lysate

Cat.No. : APBB1-8804HCL
  • Specification
  • Gene Information
  • Related Products
Description : Antigen standard for amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) (APBB1), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) [ Homo sapiens ]
Official Symbol : APBB1
Synonyms : APBB1; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); RIR; amyloid beta A4 precursor protein-binding family B member 1; Fe65; stat-like protein; adaptor protein FE65a2; FE65; MGC:9072;
Gene ID : 322
mRNA Refseq : NM_001164
Protein Refseq : NP_001155
MIM : 602709
UniProt ID : O00213
Chromosome Location : 11p15
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;
Function : beta-amyloid binding; beta-amyloid binding; chromatin binding; histone binding; proline-rich region binding; protein binding; transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (19)

Ask a question
Does APBB1 involve signal transduction pathways? 11/24/2022

APBB1 are involved in mitochondrial and Wnt signaling pathways.

What is the function and mechanism of APBB1 ? 11/23/2022

Recombinant APBB1 protein is a transcription factor associated with biological processes such as protein breakdown, signaling, and the cell cycle. Its main function is to participate in the regulation of transcription and RNA stability.

Is the APBB1 gene associated with genetic susceptibility to cancer? 07/31/2022

Mutations in the APBB1 gene are thought to be a risk gene for certain cancers and diseases such as Alzheimer's disease.

Is there gene tailoring of APBB1 in humans? If so, what is their molecular phenotype? 04/23/2022

The APBB1 gene is known to have multiple tailoring exons. In humans, there may be variable splicing of APBB1 gene.

Are there any drugs that target APBB1 ? If so, what is their mechanism of action? 04/01/2022

There are currently no drugs on the market that target the APBB1. At the same time, some researchers are exploring molecules related to APBB1 to develop drugs to treat diseases associated with it.

What is the mechanism of action of APBB1 in the treatment of Alzheimer's disease? 01/19/2022

APBB1 is involved in regulating the metabolism and transport of Alzheimer's disease-associated Aβ peptides and may be a therapeutic target for Alzheimer's disease.

In what diseases does recombinant APBB1 play an important role? 11/15/2021

The APBB1 has been studied in relation to many diseases, including Alzheimer's disease, cancer and cardiovascular disease.

In which organs is the expression of APBB1 high? 10/17/2021

APBB1 is highly expressed in tissues such as brain, heart and lung.

Has any study confirmed the correlation between APBB1 and the mutation of the gene encoding APP? 09/10/2021

Variations in both the APBB1 gene and the APP gene are considered risk genes for Alzheimer's disease.

What are the biological pathways associated with APBB1 ? 08/24/2021

APBB1 is associated with the amyloid precursor protein metabolic pathway (APP).

Is there any modern technology that can achieve the effect of treating and preventing related diseases by gene editing APBB1? 11/25/2020

The use of gene editing technology to study APBB1 to treat and prevent related diseases is a research hotspot in recent years.

Is there any research to prove that APBB1 can play an important role in anticancer therapy? 10/19/2020

APBB1 has been shown to be involved in a number of cell cycle and apoptosis pathways, so it may hold promise as a new target for cancer therapy.

Is there a specific antibody that can be used to detect APBB1 ? 09/21/2020

There are currently no specific antibodies available for the detection of APBB1 .

Are there any diseases associated with APBB1 gene mutation? If so, what are they? 12/21/2019

Mutations in the APBB1 gene are thought to be associated with diseases such as cancer and Alzheimer's disease.

What is the mechanism of action of APBB1 in cardiovascular disease? 09/08/2019

APBB1 is involved in signaling pathways in the occurrence and development of cardiovascular diseases such as myocardial hypertrophy and myocardial fibrosis.

Is APBB1 related to apoptosis? If so, what are their mechanisms? 06/28/2019

APBB1 may be involved in the regulation of apoptosis.

What is the role of APBB1 in tumor growth? 06/19/2019

APBB1 protein may act as a tumor inhibitor and participate in the regulation of cell cycle progression and apoptosis.

Are there any studies to control dementia symptoms associated with Alzheimer's disease by regulating the recombinant APBB1 protein? 04/15/2019

It has been shown that the impairment of cognitive function associated with Alzheimer's disease can be mitigated by regulating the APBB1.

Is there any research to prove that APBB1 can promote the regeneration of cardiovascular organs? 03/29/2019

At present, there are no studies to prove the mechanism of APBB1 promoting cardiovascular organ regeneration.

Customer Reviews (4)

Write a review
Reviews
12/08/2021

    APBB1 they produce has strong anti-pollution ability and is safe to use.

    02/21/2020

      Band position of APBB1 in Western blot was consistent with the expectation, showing good target recognition ability.

      12/14/2019

        Catalytic activity of APBB1 is very strong, which can significantly improve the yield of chemical reactions and reduce costs, and its economic value is outstanding.

        08/03/2019

          After using this APBB1, my experiment repeatability is very good, which is convenient for subsequent data analysis and experimental operation.

          Ask a Question for All APBB1 Products

          Required fields are marked with *

          My Review for All APBB1 Products

          Required fields are marked with *

          0

          Inquiry Basket

          cartIcon
          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends