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Recombinant Human Histidyl-tRNA synthetase

Cat.No. : HARS-46H
Product Overview : Recombinant Human Histidyl-tRNA Synthetase produced inE.Coliis a single, non-glycosylated, polypeptide chain having a molecular mass of 55 kDa. The Histidyl-tRNA Synthetase is purified by proprietary chromatographic techniques.
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Cat. No. : HARS-46H
Description : Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered clear solution.
Purity : Greater than 90.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : The protein solution (0.74 mg/ml) contains 150 mM NaCl and 10 mM sodium phosphate containing 0.1% NaN3 (pH 7.2).
Protein Content : Protein quantitation was carried out by using 0.25 - 2.0 mg/ml Bradford assay vs. BSA.
Western Blot : Strongly reactive with human anti Histidyl-tRNA Synthetase antisera.
Stability : Lyophilized Histidyl-tRNA Synthetase although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name : HARS histidyl-tRNA synthetase [ Homo sapiens ]
Synonyms : HARS; histidyl-tRNA synthetase; HRS; FLJ20491; histidine tRNA ligase 1, cytoplasmic; EC 6.1.1.21; HisRS; histidine-tRNA ligase
Gene ID : 3035
mRNA Refseq : NM_002109
Protein Refseq : NP_002100
MIM : 142810
UniProt ID : P12081
Chromosome Location : 5q31.3
Pathway : Aminoacyl-tRNA biosynthesis; Gene Expression
Function : ATP binding; histidine-tRNA ligase activity; histidine-tRNA ligase activity; nucleotide binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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