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Recombinant Human Histidyl-tRNA synthetase

Cat. No.: HARS-46H
Product Overview: Recombinant Human Histidyl-tRNA Synthetase produced inE.Coliis a single, non-glycosylated, polypeptide chain having a molecular mass of 55 kDa. The Histidyl-tRNA Synthetase is purified by proprietary chromatographic techniques.
Description: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
Source: Escherichia Coli.
Physical Appearance: Sterile Filtered clear solution.
Purity: Greater than 90.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: The protein solution (0.74 mg/ml) contains 150 mM NaCl and 10 mM sodium phosphate containing 0.1% NaN3 (pH 7.2).
Protein Content: Protein quantitation was carried out by using 0.25 - 2.0 mg/ml Bradford assay vs. BSA.
Western Blot: Strongly reactive with human anti Histidyl-tRNA Synthetase antisera.
Stability: Lyophilized Histidyl-tRNA Synthetase although stable at 4°C for 3 weeks, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Gene Name: HARS histidyl-tRNA synthetase [ Homo sapiens ]
Synonyms: HARS; histidyl-tRNA synthetase; HRS; FLJ20491; histidine tRNA ligase 1, cytoplasmic; EC 6.1.1.21; HisRS; histidine-tRNA ligase
Gene ID: 3035
mRNA Refseq: NM_002109
Protein Refseq: NP_002100
MIM: 142810
UniProt ID: P12081
Chromosome Location: 5q31.3
Pathway: Aminoacyl-tRNA biosynthesis; Gene Expression
Function: ATP binding; histidine-tRNA ligase activity; histidine-tRNA ligase activity; nucleotide binding

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