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Recombinant Human ALPP

Cat.No. : ALPP-53H
Product Overview : Recombinant Human Placental Alkaline Phosphatase encoding 154-287 amino acids expressed inE.coli.
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  • Gene Information
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Cat. No. : ALPP-53H
Description : Placental alkaline phosphatase (PLAP) is a membrane-associated siaglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85% homology with PLAP itself. PLAP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It is also commonly expressed in germ cell tumors and more recently described in seminomas.
Source : Escherichia Coli.
Physical Appearance : Sterile filtered liquid.
Formulation : PLAP at 100 µg/ml in 50 mM Tris-Acetate, pH7.5, 1 mM EDTA and 20% Glycerol.
Characterization : On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 41 kDa.
Stability : Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Gene Name : ALPP alkaline phosphatase, placental (Regan isozyme) [ Homo sapiens ]
Synonyms : ALPP; alkaline phosphatase, placental (Regan isozyme); ALP; PALP; PLAP; FLJ61142; Alkaline phosphatase, placental type;PLAP-1; Alkaline phosphatase Regan isozyme; EC 3.1.3.1; glycerophosphatase; placental alkaline phosphatase; alkaline phosphomonoesterase
Gene ID : 250
mRNA Refseq : NM_001632
Protein Refseq : NP_001623
UniProt ID : P05187
Chromosome Location : 2q37
MIM : 171800
Pathway : Folate biosynthesis; Metabolic pathways; gamma-Hexachlorocyclohexane degradation
Function : alkaline phosphatase activity; hydrolase activity; magnesium ion binding; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can ALPP serve as a diagnostic biomarker or therapeutic target for specific diseases? 01/26/2022

ALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.

How does ALPP contribute to the metabolism and turnover of its substrate(s) in physiological and pathological conditions? 11/28/2021

ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.

What are the downstream signaling pathways and molecular interactions regulated by ALPP in cellular functions? 12/22/2020

ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.

What are the regulatory mechanisms controlling ALPP gene expression and enzyme activity? 12/15/2020

ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.

What is the subcellular localization and trafficking of ALPP within cells? 11/09/2019

ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.

Can ALPP activity be modulated by specific factors or inhibitors, and how does this impact cellular processes? 07/17/2019

ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.

How does ALPP deficiency or dysregulation contribute to the pathogenesis of diseases and disorders? 07/16/2019

ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.

How can ALPP activity and function be manipulated to modulate cellular processes and disease outcomes? 09/12/2018

Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.

How does ALPP expression and activity change during development, differentiation, and disease progression? 07/08/2018

ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.

What is the expression pattern of ALPP in different tissues and cell types? 01/28/2017

ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.

Customer Reviews (3)

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Reviews
12/01/2020

    High-throughput screening compatibility.

    11/05/2018

      Consistent protein expression analysis.

      10/25/2017

        Precise protein quantification in ELISA.

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