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Recombinant Human ALPP

Cat. No.: ALPP-53H
Product Overview: Recombinant Human Placental Alkaline Phosphatase encoding 154-287 amino acids expressed inE.coli.
Description: Placental alkaline phosphatase (PLAP) is a membrane-associated siaglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85% homology with PLAP itself. PLAP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It is also commonly expressed in germ cell tumors and more recently described in seminomas.
Source: Escherichia Coli.
Physical Appearance: Sterile filtered liquid.
Formulation: PLAP at 100 µg/ml in 50 mM Tris-Acetate, pH7.5, 1 mM EDTA and 20% Glycerol.
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 41 kDa.
Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Gene Name: ALPP alkaline phosphatase, placental (Regan isozyme) [ Homo sapiens ]
Synonyms: ALPP; alkaline phosphatase, placental (Regan isozyme); ALP; PALP; PLAP; FLJ61142; Alkaline phosphatase, placental type;PLAP-1; Alkaline phosphatase Regan isozyme; EC 3.1.3.1; glycerophosphatase; placental alkaline phosphatase; alkaline phosphomonoesterase
Gene ID: 250
mRNA Refseq: NM_001632
Protein Refseq: NP_001623
UniProt ID: P05187
Chromosome Location: 2q37
MIM: 171800
Pathway: Folate biosynthesis; Metabolic pathways; gamma-Hexachlorocyclohexane degradation
Function: alkaline phosphatase activity; hydrolase activity; magnesium ion binding; zinc ion binding

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